%0 Journal Article
%T The progress of research into interleukin gene polymorphism associated with stroke
%A Chen CHEN
%A Xiao-Yuan QIAO
%A Guang-xi SHANG
%A Jin-Tao WANG
%J Medical Journal of Chinese People's Liberation Army
%D 2013
%I Editorial Board of Medical Journal of Chinese People's Liberation Army
%X As a common disease, stroke seriously impairs human health. Interleukin (IL) is an important type of inflammatory mediators, which is involved in the pathogenesis of stroke. With the study of genomics, we discovered that some gene loci of IL were associated with stroke, such as IL-1¦Á-889 C/T, IL-1RN rs380092 and IL-10-1082 G/G. Meanwhile, some gene loci of IL might become independent risk factors of stroke, such as IL-4 C582T and IL4-589C>T. Therefore, the IL gene polymorphism had become a research focus in pathogenesis of stroke. Our paper describes the relationship between IL subtype and its gene polymorphism with stroke. We look forward to provide a useful information for further research.
%K cerebrovascular accident
%K interleukins
%K inflammation mediators
%K polymorphism
%K single nucleotide
%U http://www.plamj.org/index.php/plamj/article/view/639