%0 Journal Article %T Efeito das tinturas de caf¨¦ torrado e mo¨ªdo nos n¨ªveis s¨¦ricos de colesterol, triglicer¨ªdeos e glicose em ratos diab¨¦ticos %A LUCIANA MARQUES CARDOSO %A TaNIA TOLEDO DE OLIVEIRA %A ALO¨ªSIO DA SILVA PINTO %A AGNALDO RODRIGUES DE MELO CHAVES %J Revista de Ci¨ºncias Farmac¨ºuticas B¨¢sica e Aplicada %D 2011 %I Universidade Estadual Paulista %X O consumo de caf¨¦ tem sido associado ao menor risco de diabetes tipo 2 (DM2). Evid¨ºncias epidemiol¨®gicas sugerem que o alto consumo de caf¨¦ pode reduzir o risco de diabetes mellitus. O presente trabalho teve como objetivo avaliar o efeito de tinturas de caf¨¦ torrado e mo¨ªdo nos n¨ªveis plasm¨¢ticos de colesterol, triglicer¨®is e glicose em ratos diab¨¦ticos. A indu o do diabetes foi realizada atrav¨¦s da administra o intraperitoneal de aloxano e as tinturas foram elaboradas utilizando caf¨¦ torrado e mo¨ªdo. Ap¨®s 30 dias de tratamento, foram realizadas determina es bioqu¨ªmicas. As tinturas de caf¨¦ sol¨²vel promoveram aumento nos n¨ªveis de colesterol e as percentagens de redu o das concentra es de glicose e triacilglicer¨ªdeo variaram entre 20 e 24% e entre 51 a 57%, respectivamente. A partir dos resultados obtidos, concluiu-se que os tratamentos com o caf¨¦ sol¨²vel sustentam a hip¨®tese de que o caf¨¦ est¨¢ associado ao menor risco de DM2. Palavras-chave: Tinturas. Caf¨¦. Diabetes. ABSTRACT Effect of tincture of ground roasted coffee on plasma levels of cholesterol, triglycerides and glucose in diabetic rats The consumption of coffee has been associated with a lower risk of type 2 diabetes (DM). Epidemiological evidence suggests that high consumption of coffee may reduce the risk of diabetes. The aim of this study was to assess the effects of a tincture (hydroethanolic extract) of roasted and ground coffee on plasma levels of cholesterol, triglycerides and glucose in diabetic rats. The diabetes was induced by intraperitoneal administration of alloxan. The induced diabetic rats were then treated for 30 days by gavage with various doses of the coffee tincture. After the treatment, biochemical blood tests were carried out on the rats. The coffee tincture provoked moderately increased levels of cholesterol, but the concentrations of glucose and triglycerides were reduced by 20-24% and 51-57%, respectively. From these results, it was concluded that the treatment with coffee extract supports the hypothesis that coffee is associated with a lower risk of type 2 DM. Keywords: Tinctures. Coffee. Diabetes. %K Farmacologia %K tinturas %K caf¨¦ %K diabetes. %U http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/1005