%0 Journal Article
%T DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL SULPHATE
%A Arya R. K
%A Chaurasia H.
%A Bharadwaj P
%A Garud N
%J International Research Journal of Pharmacy
%D 2011
%I International Research Journal of Pharmacy
%X Prime object of present study was to develop and evaluate mucoadhesive tablets of Salbutamol Sulphate by non aqueous granulation of polymers HPMC K-4M (Hydroxypropyl Methyl Cellulose) and Chitosan in different ratios (1:1. 1:2 & 2:1). The tablets were evaluated for weight variation, hardness, thickness, drug content uniformity, mucoadhesion and swelling index. Swelling index of batches containing more HPMC K-4M was greater than that of containing less HPMC K-4M. In vitro bioadhesive strength studies showed that tablets containing more HPMC K-4M were excellent in bioadhesive nature. The in-vitro drug release was studied in phosphate buffer (pH 6.8). And all batches were subjected to release kinetics model fitting.
%K Mucoadhesive
%K Salbutamol sulphate
%K Buccal tablet
%K HPMC
%K Swelling index
%K Bioadhesive
%U http://irjponline.com/volume2/27.pdf