%0 Journal Article
%T Investigation on nitric oxide and C-reactive protein involvement in anti-leishmanial effects of artemisinin and glucantim on cutaneous leishmaniasis
%A S. Nemati
%A H. Nahrevanian
%A A. Haniloo
%A M. Farahmand
%J Advanced Studies in Biology
%D 2013
%I 
%X Cutaneous leishmaniasis (CL), a dermatological parasitic infection caused byLeishmania major and L .tropica. This disease is still one of the health problemsin the tropical and sub tropical parts of world, region and Iran. Although,artemisinin (qinghaosu) is widely used as anti-malarial agent, it is alsodemonstrated its anti-promastigote effects on some leishmania species.Inflammatory responses against leishmania consist of chemokines, immune cellsand mediators. This study investigates two immunological pathways includingnitric oxide (NO) and C-reactive protein (CRP) in L. major infected Balb/c micefollowing treatment with artemisinin and glucantim. Plasma was investigated forNO and CRP alterations using Griess Micro Assay (GMA) and Latex Agglutinations Test (LAT) respectively. The results indicated a significant declinein NO levels due to atemisinin treatment (P¡Ü0.05) and in untreated group(P¡Ü0.05). No changes in CRP were observed in experimental groups. It isindicated that L. major infection naturally decreased NO induction in Balb/c miceas a result of amastigote action; therefore artemisinin was not able to increase NOto combat parasite. It is concluded that artemisinin/glucantim action in CL wasnot associated with NO and CRP pathways; however more studies are needed toclarify other immunological parameters.
%K Artemisinin
%K Glucantim
%K Leishmaniasis
%K Leishmani major
%K NO
%K CRP
%U http://www.m-hikari.com/asb/asb2013/asb1-4-2013/nahrevanianASB1-4-2013.pdf