%0 Journal Article %T Efecto de un extracto oleoso de rizoma de Zingiber officinale Roscoe (MVZ) sobre la anafilaxia pasiva cut芍nea y el espasmo bronquial inducido por histamina Effect of an oleosus extract of rhizome of Zingiber officinale Roscoe (MVZ) on the cutaneous passive anaphylaxis and the bronchial spasm induced by histamine %A Yanier N迆ˋez Figueredo %A Juana Till芍n Cap車 %A Carmen Carrillo Dom赤nguez %A Odila A Olivares Guerra %J Revista Cubana de Plantas Medicinales %D 2005 %I ECIMED %X Para demostrar las propiedades antial谷rgicas conferidas al MVZ, se estudi車 su posible influencia sobre los mediadores anafil芍cticos y el espasmo bronquial inducido por histamina. En la prueba de anafilaxia pasiva cut芍nea se emplearon ratas Wistar machos a las cuales se les administr車 el MVZ a la dosis de 6,5 mL/kg (4,8 g de 芍cidos grasos/kg) por v赤a oral durante 10 d赤as, se emple車 como control positivo ketotifeno 3 mg/kg, la intensidad de la anafilaxia se determin車 cuantificando la cantidad de azul de Evans extravasado. El efecto protector del espasmo bronquial se determin車 en cobayos Hartley machos, induciendo brococonstricci車n por administraci車n intravenosa de histamina y determinando la presi車n bronquial; la dosis del producto empleada fue la misma que para el ensayo anterior. Como resultado de este trabajo se encontr車 que el MVZ inhibi車 la anafilaxia pasiva cut芍nea en ratas y la broncoconstricci車n inducida por 15 米g/kg de histamina por v赤a endovenosa. Los resultados obtenidos sugieren que el MVZ pudiera ser efectivo en el tratamiento profil芍ctico de enfermedades al谷rgicas tipo I como el asma bronquial, lo cual justificar赤a su uso popular en pacientes asm芍ticos. In order to show the antiallergic properties conferred to MVZ, it was studied its posible influence on the anaphylactic mediators and the bronchial spasm induced by histamine. In the test of cutaneous passive anaphylaxis there were used Wistar male rats that were orally administered MVZ at a dose of 6.5 mL/kg (4.8 of fatty acids/kg) during 10 days. Ketotifen 3 mg/kg was used as a positive control. The intensity of anaphylaxis was determined by quantifying the amount of extravasated Evans blue.The protective effect of bronchial spasm was determined in Hartley male guinea pigs by inducing brochoconstriction through the intravenous administration of histamine and estimating the bronchial pressure. The dose of the product used was the same as that of the previous assay. As a result, it was found that MVZ inhibited the cutaneous passive anaphylaxis in rats and the bronchoconstriction induced by 15 米g/kg of histamine by endovenous route. The outcomes suggest that the MVZ may be effective in the prophylactic treatment of type 1 allergic diseases, such as bronchial asthma, which would justify its popular use in asthmatic patients. %K Zingiber officinale Roscoe %K MVZ %K anafilaxia pasiva cut芍nea %K espasmo bronquial %K %K histamina %K Zingiber officinale Roscoe %K MVZ %K cutaneous passive anaphylaxis %K bronchial spasm %K histamine %U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962005000300006