%0 Journal Article
%T MORPHOMETRICAL AND STEREOLOGICAL ANALYSIS OF THE SUPERIOR CERVICAL GANGLION OF Rattus norvegicus SUBMITTED TO CHRONIC TREATMENT WITH CORTISOL AN¨¢LISIS MORFOM¨¦TRICO Y ESTEREOL¨®GICO DEL GANGLIO CERVICAL SUPERIOR DE Rattus norvegicus SOMETIDO A TRATAMIENTO CR¨®NICO CON CORTISOL
%A C. M. Cortez
%A W. S. Costa
%A M. A. Babinski
%A M. A. Chagas
%J International Journal of Morphology
%D 2003
%I Sociedad Chilena de Anatom¨ªa
%X The present work investigates the corticoid action on the growth of the superior cervical ganglion of the rat and describes the cortisol effect during early stages of development. The study was based on morphometric and stereological analysis of the perikarya. Eight rats were treated intraperitoneally with cortisol (1mg/Kg/day) during 36 days. Treatment was initiated in the 8th day after birth and was withdrawn one day before the sacrifice. There was a significant difference (<=P0,05) for the neural mean diameter between the control group (16.78 ¡À 1.11mm) and treated animals (15.84 ¡À0.99mm). The decrease of perikarya neuronal diameter was also demonstrated by stereological methods. Morphometrical findings may suggest alterations in superior cervical ganglion neuronal activity in rats treated for long term with cortisol Se investig¨® la acci¨®n de corticoides en el crecimiento del ganglio cervical superior de rata y se describieron los efectos del cortisol durante las fases tempranas de desarrollo. El estudio se bas¨® en los an¨¢lisis morfom¨¦trico y estereol¨®gico del pericario. Fueron inyectadas intraperitonealmente 8 ratas con cortisol (1mg/Kg/d¨ªa) durante 36 d¨ªas. El tratamiento se comenz¨® en el d¨ªa 8 despu¨¦s del nacimiento, finaliz¨¢ndose un d¨ªa antes del sacrificio. Hubo una diferencia significativa (<=P0,05) en el promedio del di¨¢metro neuronal entre el grupo control (16.78 ¡À 1.11 mm) y los animales tratados (15.84 ¡À 0.99 mm). La disminuci¨®n del di¨¢metro neuronal del pericario tambi¨¦n fue demostrada a trav¨¦s de la estereolog¨ªa. Los hallazgos morfom¨¦tricos pueden hacer pensar en alteraciones de la actividad neuronal del ganglio cervical superior, en ratas tratadas por un largo periodo con cortisol
%K Morfometr¨ªa
%K Estereolog¨ªa
%K Glicocorticoide
%K Ganglio simp¨¢tico
%K Rata
%K Morphometry
%K Stereology
%K Glucocorticoid
%K Sympathetic ganglion
%K Rat
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000300006