%0 Journal Article
%T The baboon (Papio anubis) extracranial carotid artery: An anatomical guide for endovascular experimentation
%A J Mocco
%A Daniel J Hoh
%A M Nathan Nair
%A Tanvir F Choudhri
%A William J Mack
%A Ilya Laufer
%A E Sander Connolly
%J BMC Cardiovascular Disorders
%D 2001
%I BioMed Central
%R 10.1186/1471-2261-1-4
%X We characterized the extracranial carotid system often male baboons (Papio anubis, range 15.1¨C28.4 kg) by early post-mortem dissection. Photographic documentation of vessel lengths, lumen diameters, and angles of origin were measured for each segment of the carotid bilaterally.The common carotid arteries averaged 94.7 ¡À 1.7 mm (left) and 87.1 ¡À 1.6 mm (right) in length. The average minimal common carotid lumen diameters were 3.0 ¡À 0.3 mm (left) and 2.9 ¡À 0.2 mm (right). Each animal had a common brachiocephalic artery arising from the aorta which bifurcated into the left common carotid artery and right braciocephalic artery after 21.5 ¡À 1.6 mm. The vascular anatomy was found to be consistent among animals despite a wide range of animal weights.The consistency in the Papio anubis extracranial carotid system may promote the use of this species in the preclinical investigation of neuro-interventional therapies.There has been a recent interest in developing aggressive interventional strategies for the treatment of a variety of neurological diseases including stroke, subarachnoid hemorrhage, and head trauma [1-4]. Successful translation of these therapies to the clinical arena, however, is critically dependent on the use of appropriate experimental models [5]. Non-human primate models of neurological diseases currently exist and have the advantage of most closely mimicking human physiology [6]. These models are particularly relevant to neuro-interventional research in that anatomical similarities permit routine vascular access and evaluation of devices designed on a clinically relevant scale.Conducting experimental primate endovascular studies, however, requires a comprehensive understanding of the carotid vascular system. Previous investigations of non-human primate vascular anatomy have focused primarily on the general morphology of the vessels and not on vessel angles, lengths, or lumen diameters which are necessary for guiding endovascular technology [7,8]. To answer
%U http://www.biomedcentral.com/1471-2261/1/4