%0 Journal Article
%T The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population
%A Hack-Lyoung Kim
%A Moon-Sun Im
%A Jae-Bin Seo
%A Woo-Young Chung
%A Sang-Hyun Kim
%A Myung-A Kim
%A Joo-Hee Zo
%J Cardiovascular Ultrasound
%D 2013
%I BioMed Central
%R 10.1186/1476-7120-11-2
%X A total of 115 healthy subjects without known cardiovascular risk factors or overt heart disease who underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity (baPWV) measurement at the same day during their routine check-ups were analyzed.The mean age of study subjects was 52.8 ¡À 8.4 years, and 78 (67.8%) were men. The mean baPWV value was 1,325 ¡À 185 cm/s. Study subjects were divided into 3 groups according to E/E¡¯ value: subjects with E/E¡¯ < 8, 8¨C12.9 and E/E¡¯ ¡Ý 13. As E/E¡¯ increased, baPWV value increased gradually: baPWV in subjects with E/E¡¯ < 8, E/E¡¯ 8¨C12.9 and E/E¡¯ ¡Ý 13, were 1,261 ¡À 163, 1,345 ¡À 169, 1,569 ¡À 232 cm/s, respectively (p < 0.001). In multiple linear regression analyses, baPWV was significantly associated with E/E¡¯ (¦Â = 0.371, p < 0.001) after controlling confounders including age, sex and body mass index. In receiver-operating characteristic (ROC) curve analysis, the sensitivity and specificity for detection of E/E¡¯ ¡Ý 10 were 78.6% and 59.8%, respectively with mean baPWV of 1,282 cm/s as the cut off value. The discriminatory capacity for predicting E/E¡¯ ¡Ý 10 was improved from an area under the ROC curve of 0.646 with age alone to 0.734 when baPWV was added (p < 0.001).There is a significant association between baPWV and E/E¡¯ in an apparently healthy Korean population. BaPWV is useful as a simple and non-invasive method for early detection of increased LV filling pressure among these people.Stiffened artery increases pulse pressure leading to left ventricular hypertrophy and coronary artery disease [1]. Arterial stiffness has been reported to be associated with cardiovascular morbidity and mortality [2,3].There are several methods to estimate arterial stiffness. Among them, pulse wave velocity (PWV) is generally accepted as the most simple, non-invasive and validated indicator of arterial stiffness [4,5]. Recently, the brachial-ankle PWV (baPWV) measurement, which is easy to perform, has become available in clinical pr
%K Arterial stiffness
%K Association
%K Left ventricular filling pressure
%K Pulse wave velocity
%U http://www.cardiovascularultrasound.com/content/11/1/2