%0 Journal Article
%T Temporal changes in concentrations of lipids and apolipoprotein B among adults with diagnosed and undiagnosed diabetes, prediabetes, and normoglycemia: findings from the National Health and Nutrition Examination Survey 1988每1991 to 2005每2008
%A Earl S Ford
%A Chaoyang Li
%A Allan Sniderman
%J Cardiovascular Diabetology
%D 2013
%I BioMed Central
%R 10.1186/1475-2840-12-26
%X We used data from 3202 participants aged ≡20 years from the National Health and Nutrition Examination Survey (NHANES) III (1988每1991) and 3949 participants aged ≡20 years from NHANES 2005每2008.Among participants of all four groups, unadjusted and adjusted mean concentrations of total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B, but not triglycerides, decreased significantly. Among participants with prediabetes and normoglycemia, unadjusted and adjusted mean concentrations of high-density lipoprotein cholesterol increased significantly. Adjusted mean log-transformed concentrations of triglycerides decreased in adults with undiagnosed diabetes and prediabetes. During 2005每2008, unadjusted concentrations of apolipoprotein B ≡80 mg/dl were observed in 72.8% of participants with diagnosed diabetes, 87.9% of participants with undiagnosed diabetes, 86.6% of participants with prediabetes, and 77.2% of participants with normoglycemia. The unadjusted use of cholesterol-lowering medications rose rapidly, especially among participants with diabetes (from ~1% to ~49%, P <0.001). The use of fenofibrate, gemfibrozil, and niacin rose significantly only among adults with diagnosed diabetes (from ~2% to ~8%, Pˋ=ˋ0.011).Lipid profiles of adults with diabetes improved during the approximately 16-year study period. Nevertheless, large percentages of adults continue to have elevated concentrations of apolipoprotein B.During the last several decades, diabetes has emerged as a major public health problem in the United States as the incidence and prevalence of obesity has escalated rapidly [1,2]. The lifetime probability of developing this disease is approximately 32.8% for men and 38.5% for women [3], and an estimated 25.6 million adults have diabetes [4]. Furthermore, diabetes has an enormous impact on health care costs in the United States; in 2007, for example, the economic costs attributable to this condition were est
%K Apolipoprotein B
%K Cholesterol
%K Diabetes
%K High-density lipoprotein cholesterol
%K Lipids
%K Prediabetes
%K Triglycerides
%K Fenofibrate
%K Gemfibrozil
%K Niacin
%U http://www.cardiab.com/content/12/1/26