%0 Journal Article
%T AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARgamma
%A Vedat Tiyerili
%A Ulrich M Becher
%A Adem Aksoy
%A Dieter L¨štjohann
%A Sven Wassmann
%A Georg Nickenig
%A Cornelius FH Mueller
%J Cardiovascular Diabetology
%D 2013
%I BioMed Central
%R 10.1186/1475-2840-12-30
%X Methods and results: ApoE-/- and ApoE-/-/AT1R-/--mice were rendered diabetic by intraperitoneal injections of streptozotocin. Diabetic and non-diabetic ApoE-/--mice were further randomized to receive the AT1R antagonist telmisartan, the selective PPARgamma antagonist GW9662, telmisartan and GW9662 or vehicle for 18 weeks. Diabetic and non-diabetic ApoE-/-/AT1R-/--mice were randomized to receive either GW9662 or vehicle. GW9662 treatment in diabetic ApoE-/- and diabetic ApoE-/-/AT1-/--mice resulted in the highest elevation of fasting blood glucose levels, whereas telmisartan treatment and AT1 deficiency in ApoE-/--mice showed the lowest fasting blood glucose levels. Diabetic ApoE-/--mice displayed severe impairment of endothelial function, enhanced oxidative stress and increased atherosclerotic lesion formation. ApoE-/-/AT1R-/- and telmisartan-treated ApoE-/--mice showed a significantly better endothelial function, decreased oxidative stress and reduced atherosclerotic lesion formation. Treatment of diabetic ApoE-/- and ApoE-/-/AT1R-/--mice with the selective PPARgamma antagonist GW9662 omitted the atheroprotective effects of AT1R deficiency or AT1 antagonism.Genetic disruption or pharmacological inhibition of the AT1R attenuates atherosclerosis and improves endothelial function in diabetic ApoE-/--mice via the PPARgamma pathway.
%U http://www.cardiab.com/content/12/1/30/abstract