%0 Journal Article
%T The oleic acid esterification of policosanol increases its bioavailability and hypocholesterolemic action in rats
%A Haim
%A D.
%A Valenzuela
%A A.
%A Braˋes
%A M. C.
%A Fuenzalida
%A M.
%J Grasas y Aceites
%D 2012
%I Consejo Superior de Investigaciones Cient赤ficas
%R 10.3989/gya.010612
%X Policosanol comprises a mixture of long-chain aliphatic alcohols from sugarcane wax. More than 50 studies indicate that policosanol decreases serum cholesterol, while others failed to reproduce this effect. The objective of this investigation was to assess the bioavailability of esterified policosanol and non-esterified policosanol (NEP), in relation to their hypocholesterolemic effects. Sprague Dawley rats were given a daily oral dose of 100 mg/kg of NEP, 117 mg kg每1 of butyric acid esterified policosanol (BAEP), or 164 mg kg每1 of oleic acid esterified policosanol (OAEP). Policosanol absorption was evaluated in plasma between 0 and 3 hours after ingestion. To assess changes in total cholesterol, LDL-cholesterol, HDLcholesterol and triacylglycerols in plasma and liver 3-hydroxy- 3-methylglutaryl coenzyme A reductase (HMG- CoA red) phosphorylation, the rats were supplemented with nonesterified or esterified policosanol for 5 weeks. The results indicate that policosanol absorption was significantly greater in OAEP-treated rats than in those subjected to NEP or BAEP administration. OAEP significantly reduced plasma total and LDL-cholesterol in rats, in addition to a 5.6-fold increase (P < 0.05) in the hepatic content of phosphorylated HMG-CoA red over the control values. In conclusion, esterification of policosanol with oleic acid enhances policosanol bioavailability, and significantly improves the serum lipid profile in normocholesterolemic rats in association with the inactivation of HMG-CoA red controlling cholesterogenesis. Los Policosanoles est芍n formados por una mezcla de alcoholes alif芍ticos de cadena larga y se obtienen de las ceras de la ca a de az迆car. M芍s de cincuenta estudios indican que los policosanoles reducen el colesterol s谷rico, mientras que otros no logran reproducir este efecto. El objetivo de esta investigaci車n fue evaluar la biodisponibilidad de policosanoles esterificados y no esterificados (NEP), en relaci車n con sus efectos hipocolesterol谷micos. Para ello, a ratas Sprague Dawley se les administr車 una dosis oral diaria de 100 mg kg每1 de NEP, 117 mg kg每1 de policosanoles esterificados con 芍cido but赤rico (BAEP), 車 164 mg kg每1 de policosanoles esterificados con 芍cido oleico (OAEP). La absorci車n de los policosanoles se evalu車 en el plasma entre 0 y 3 horas despu谷s de la ingesti車n. Para evaluar los cambios en el colesterol total, colesterol-LDL, colesterol-HDL y triglic谷ridos en el plasma y en la fosforilaci車n de la h赤gado 3-hidroxi-3-metilglutaril coenzima A reductasa (HMG-CoA red), la ingesta de las ratas fue suplementada con policosano
%K Bioavailability
%K Cholesterol lowering effect
%K Octacosanol
%K Policosanol
%K Policosanol absorption
%K Rats
%K Triacontanol
%K Absorci車n de Policosanoles
%K Biodisponibilidad
%K Efecto reductor de colesterol
%K Octacosanol
%K Policosanol
%K Triacontanol
%K Ratas
%U http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388/1384