%0 Journal Article %T Antihyperlipidemic and Hepatoprotective Activity of Dodonaea viscosa Leaves Extracts in Alloxan-Induced Diabetic Rabbits (Oryctolagus cuniculus) %A Maqsood Ahmad %A Qaisar Mahmood %A Kamran Gulzar1 %A Muhammad Shoaib Akhtar1 %A Mohammad Saleem and Muhammad Imran Qadir* %J Pakistan Veterinary Journal %D 2012 %I University of Agriculture, Faisalabad %X Hyperlipidemia is associated with diabetes and hepatotoxicity has emerged as a common clinical complication by antidiabetics. The present study was conducted to determine the antihyperlipidemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in the alloxan-induced diabetic rabbits. The rabbits (n = 70) were divided into seven groups including normal and diabetic control, the remaining were aqueous, aqueous:methanol (70:30), aqueous:methanol (50:50), aqueous: methanol (30:70), and methanol extracts given for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, ALT and AST were estimated by using commercially available kits. The oral administration of aqueous:methanol (70:30) extract of the Dodonaea viscosa leaves significantly (P<0.01) decreased the raised parameters (triglyceride, total cholesterol and LDL-cholesterol) to normal values. But the extract has significantly increased HDL-cholesterol, ALT and AST levels. For the aqueous:methanol (70:30) extract given animals, the average serum level of total cholesterol was 60.00¡À1.30 mg/dL, LDL-cholesterol was 92.80¡À2.29 mg/dL, HDL-cholesterol was 31.80¡À1.0 mg/dL and triglyceride was 15.40¡À0.75 mg/dL while the average serum levels of ALT and AST were 45.60¡À3.08 and 27.20¡À1.36 IU/dL, respectively. It is concluded from the study that aqueous:methanolic (70:30) extract of Dodonaea viscosa leaves exerts antihy- perlipidemic and hepatoprotective effects in the alloxan-induced diabetic rabbits. %K ALT %K Antihyperlipidaemic %K AST %K Dodonaea viscose %K HDL-cholesterol %K Hepatoprotective %K LDL-cholesterol %K Rabbits %K Total cholesterol %K Triglyceride %U http://pvj.com.pk/pdf-files/32_1/50-54.pdf