%0 Journal Article
%T Protection by Liquorice in Alcohol Induced Gastric Mucosa Damage
%A A.E. Ligha
%A H.B. Fawehinmi
%J Pakistan Journal of Nutrition
%D 2009
%I 
%X Gastric diseases are widespread among the inhabitants of many countries and alcohol consumption is a known precipitating factor. This study investigates the protective effect of Liquorice, an indigenous plant in tropical and sub-tropical areas and belongs to the Fabaceae family on 80% alcohol- induce gastric mucosa lesions and morphological changes in rats. The rats were divided into five groups of five rats per group. Gastric damage was induced with 80% alcohol. The treated group received the crude extract of 200 mg/kg.oral prior to alcohol gastric mucosa damage induction. Histological studies, ulcer index, Alkaline Phosphotase (ALP), lipid peroxidation product (TBARS) which is an index of lipid peroxidation were studied. Liquorice pre-treatment showed protection against alcohol mucosa damage; a significant reduction in the ulcer index of 1.94 ¡À0.05 against 5.24 ¡À0.07 of positive control. The ALP and TBARS were also significantly reduced. The results suggest that Liquorice seed extracts have significant mucosal protective and antioxidative effects on the gastric mucosa in rats.
%K Alcohol
%K gastric lesion
%K protection
%U http://docsdrive.com/pdfs/ansinet/pjn/2009/1532-1536.pdf