%0 Journal Article %T Effects of EPA and Vitamin E on Serum Enzymatic Antioxidants and Peroxidation Indices in Patients with Type II Diabetes Mellitus %A SH Sarbolouki %A M Djalali %A AR Dorosty %A MR Eshraghian %J Iranian Journal of Public Health %D 2010 %I Tehran University of Medical Sciences %X Background: Diabetes mellitus is associated with chronic changes in peripheral arteries because of oxidative stress and insufficient antioxidative defense mechanism. Omega-3 fatty acid supplementation could be effective in some diabetes complications; however, polyunsaturated fatty acids may increase lipid peroxidation. This study aimed to determine whether eicosapentaenoic acid alone or in conjunction with vitamin E had differential effects on serum antioxidants and peroxidation indices."nMethods: This double-blind, placebo-controlled trial was carried out on 136 patients with type II diabetic mellitus (age 48.8¡À4.4 yr, BMI 27.8¡À1.7 kg/m2). The four groups of the study either received two grams of omega-3 fatty acids, 400 IU of vitamin E, a combination of the two or placebo for three months. Their serum total antioxidant capacity, enzymatic antioxidants and peroxidation indices were assessed."nResult: Fasting serum TAC increased in EPA+E (10.7%, P< 0.001) and E groups (7.5%, P< 0.05). SOD, G-PX and G-RD increased in EPA group (7.3%, 5.1%, and 8.4%, P< 0.05, respectively). MDA and protein carbonyl decreased in EPA and E groups (respectively, 12.5%, 7.6% P< 0.05, P< 0.05; 13%, 15.3% P< 0.001, P< 0.05). After adjustment for baseline values, age, sex, BMI and duration of diagnosed diabetes, protein carbonyl decreased in EPA+E and E group (30.7%, 15.3%; P< 0.05 respectively) relative to the placebo group."nConclusion: EPA, by itself has a statistically significant effect on serum total antioxidant capacity, enzymatic antioxidants and peroxidation indices in diabetic patients compared to EPA+E or E alone. Trial registration: ClinicalTrials.gov NCT00817622 %K Diabetes mellitus %K Eicosapentaenoic acid %K EPA %K Total antioxidant capacity %K Vitamin E %U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16650.pdf&manuscript_id=16650