%0 Journal Article
%T Fluctuations in the skeletal muscle power-velocity relationship and interferon-¦Ã after a muscle-damaging event in humans
%A Tyler Barker
%A Vanessa T Henriksen
%A Thomas B Martins
%A Carl R Kjeldsberg
%A Harry R Hill
%J Extreme Physiology & Medicine
%D 2012
%I BioMed Central
%R 10.1186/2046-7648-1-6
%X Nine healthy males participated in this study. Each subject had one leg randomly assigned as the control leg. The other leg served as the treatment leg and performed an intense-stretch-shortening cycling (SSC) exercise protocol to induce muscle damage. To measure muscle damage and the power-velocity relationship, unilateral peak isometric force and power output (forces and velocities) measurements were performed prior to, immediately after, and during the days following the SSC protocol. The circulating IFN-¦Ã concentrations were measured in serum samples obtained prior to, immediately after, and during the days following the SSC protocol. Statistical significance of single-leg isometric force and power output data were assessed using a two-way (time and leg treatment) analysis of variance (ANOVA) with repeated measures, followed by a Tukey¡¯s honestly significant difference (HSD) to test multiple pairwise comparisons. The statistical significance of the IFN-¦Ã data were assessed using a one-way (time) ANOVA with repeated measures, followed by a Tukey¡¯s HSD to test multiple pairwise comparisons.In the treatment leg, significant (P < 0.05) peak isometric force deficits occurred immediately and persisted several days after the SSC protocol, thereby identifying muscle damage-induced weakness. During muscle weakness in the treatment leg, peak power was significantly (P < 0.05) depressed and the velocities at peak power were significantly (P < 0.05) slower. Interestingly, circulating IFN-¦Ã concentrations decreased at 2 and 3 days after compared to those immediately following the SSC protocol.We conclude that the velocity to achieve a compromised peak power is reduced, and speculatively, the circulating IFN-¦Ã excursion could be influential on the recovery of skeletal muscle after a muscle-damaging event in humans.Skeletal muscle power is an important determinant of human locomotion. Skeletal muscle power production is velocity-dependent, and therefore, should be interpreted
%K Muscle damage
%K Interferon-¦Ã
%K Stretch-shortening contractions
%U http://www.extremephysiolmed.com/content/1/1/6