%0 Journal Article
%T Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function
%A Nathalie Dautin
%J Toxins
%D 2010
%I MDPI AG
%R 10.3390/toxins2061179
%X Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.
%K SPATE
%K autotransporters
%K pathogenic E. coli
%K Shigella
%K EspP
%K Pet
%K EspC
%K Sat
%K Vat
%K Hbp
%K EpeA
%K Pic
%K SepA
%K SigA
%K Tsh
%U http://www.mdpi.com/2072-6651/2/6/1179