%0 Journal Article
%T Study of-amyloid adsorption and aggregation on graphite by STM and AFM<br>Study of β—amyloid adsorption and aggregation on graphite by STM and AFM
%A WANGZhigang
%A WANLijun
%A ZHOUChungqing
%A FANGXiaohong
%A WANGChen
%A BAIChunli
%J 科学通报(英文版)
%D 2003
%I 
%X The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of -amyloid(1-42)(A42) on the hydrophobic graphite surface. It was found that A42 were preferentially adsorbed on graphite defects such as the edges. A42 peptides self-assembled into intermediate protofibrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation proc-ess of -amyloid.
%K sanning tunneling microscopy
%K atomic force microscopy
%K -amyloid
%K fibrillization<br>β－环糊精
%K 石墨
%K 吸附
%K 聚集
%K 扫描隧道显微镜
%K 原子力显微镜
%K 早老性痴呆
%K 药物载体
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=980CCA6059A4D5D1AA0AFEEF491E492E&yid=D43C4A19B2EE3C0A&vid=B6DA1AC076E37400&iid=94C357A881DFC066&sid=B40AD8FE6FA88DE9&eid=78976D931AD1540F&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=0