%0 Journal Article
%T Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity
%A Hosam A. Saad
%A Mohamed M. Youssef
%A Mosselhi A. Mosselhi
%J Molecules
%D 2011
%I MDPI AG
%R 10.3390/molecules16064937
%X Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4]triazinone and pyrazolo[5,1-c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS2/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, 1H-NMR, 13C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
%K 1
%K 2
%K 4-triazinone
%K thiadiazinone
%K triazinone
%K triazine carbonitrile
%K microwave synthesis
%U http://www.mdpi.com/1420-3049/16/6/4937