%0 Journal Article
%T Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)
%A Ana Silvia Suassuna Carneiro L¨²cio
%A Jackson Roberto Guedes Da Silva Almeida
%A Jos¨¦ Maria Barbosa-Filho
%A Jo£¿o Carlos Lima Rodrigues Pita
%A Marianna Vieira Sobral Castello Branco
%A Margareth De F¨¢tima Formiga Melo Diniz
%A Maria De F¨¢tima Agra
%A Emidio V.L. Da-Cunha
%A Marcelo Sobral Da Silva
%A Josean Fechine Tavares
%J Molecules
%D 2011
%I MDPI AG
%R 10.3390/molecules16087125
%X Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 ¦Ìg/mL, respectively.
%K Annonaceae
%K Anaxagorea dolichocarpa
%K azaphenanthrene alkaloid
%K antitumor activity
%U http://www.mdpi.com/1420-3049/16/8/7125