%0 Journal Article
%T Analysis of apigenin in <i>Blumea balsamifera</i> Linn DC. and its inhibitory activity against aldose reductase  in rat lens
%A Dong Gu Lee
%A So-Youn Mok
%A Changsun Choi
%A Eun Ju Cho
%A Hyun Young Kim
%A Sanghyun Lee
%J Journal of Agricultural Chemistry and Environment
%P 28-33
%@ 2325-744X
%D 2012
%I Scientific Research Publishing
%R 10.4236/jacen.2012.11005
%X <span style=\"font-family:\"Arial\",\"sans-serif\";font-size:10pt;\">To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of <i>Blumea balsamifera</i> were tested for their ability to inhibit aldose reductase (AR)<span> activity in rat lenses</span>. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC<sub>50</sub> value, 0.11 ¦Ìg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC<sub>50</sub> value, 4.03 ¦Ì<span>M</span>). <span>The content of </span>apigenin<span> was measured </span>in <i>B. balsamifera</i><span> <span>(</span></span><span>0.47 mg/g)<i> </i>by HPLC/UV analysis. Our result sug</span>gests that <i>B. balsamifera</i> could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.</span> 
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%K &lt
%K i&gt
%K Blumea balsamifera&lt
%K /i&gt
%K Apigenin
%K Aldose Reductase Inhibition
%K HPLC
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=24907