%0 Journal Article
%T A Simple and Efficient Route for Preparing 2,3,5,6-Tetraaminopyridine Hydrochloride Salt
%A Yanhong Wang
%A Zhen Hu
%A Xiangli Meng
%A Jiehui Jing
%A Yuanjun Song
%A Chunhua Zhang
%A Yudong Huang
%J Molecules
%D 2009
%I MDPI AG
%R 10.3390/molecules14051652
%X A simple and efficient route for preparing 2,3,5,6-tetraaminopyridine hydrochloride salt (TAP¡¤3HCl¡¤H2O) was introduced in this paper. The title compound was synthesized, as usual, in two steps (nitration and hydrogenation) with a total yield of 90%. The use of an oleum and fuming nitric acid mixture in the nitration step improved the yield and purity of the intermediate product. A highly efficient hydrogenation using a H2/Pd/C/C2H5OH system was developed. The products were characterized by TG, IR, 1H-NMR, 13C-NMR, HPLC and elemental analysis.
%K 2
%K 3
%K 5
%K 6-Tetraaminopyridine
%K Nitration
%K Hydrogenation
%K Synthesis
%U http://www.mdpi.com/1420-3049/14/5/1652