%0 Journal Article %T A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria %A Yan Qiu %A Xiu Min Wang %J Molecules %D 2008 %I MDPI AG %R 10.3390/molecules13061275 %X Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC50 values of 239.7, 16.4, 176.1, and 130.4 ¦ÌM, respectively, while 1 and 2 were found to be inactive against the same biological target. %K Sesquiterpenoid hydroquinone %K anti-HIV activity %K Dysidea arenaria. %U http://www.mdpi.com/1420-3049/13/6/1275