%0 Journal Article
%T Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1
%A Seicho Makihira
%A Takahiro Shuto
%A Hiroki Nikawa
%A Keishi Okamoto
%A Yuichi Mine
%A Yuko Takamoto
%A Masaru Ohara
%A Koichiro Tsuji
%J International Journal of Molecular Sciences
%D 2010
%I MDPI AG
%R 10.3390/ijms11041458
%X The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
%K antimicrobial peptide
%K titanium surface
%K MC3T3-E1 cells
%U http://www.mdpi.com/1422-0067/11/4/1458