%0 Journal Article %T Asymmetric Glyoxylate-Ene Reactions Catalyzed by Chiral Pd(II) Complexes in the Ionic Liquid [bmim][PF6] %A Xi Jun He %A Zhen Lu Shen %A Wei Min Mo %A Bao Xiang Hu %A Nan Sun %J International Journal of Molecular Sciences %D 2007 %I MDPI AG %R 10.3390/i8060553 %X The room temperature ionic liquid [bmim][PF6] was employed as the reactionmedium in the asymmetric glyoxylate-ene reaction of ¦Á-methyl styrene (4a) with ethylglyoxylate using chiral palladium(II) complexes as the catalysts. [Pd(S-BINAP)(3,5-CF3-PhCN)2](SbF6)2 (1b) showed the highest catalytic activity. Under the reaction conditionsof 40 oC, 0.5 h, and 1b/4a molar ratio of 0.05, ethyl ¦Á-hydroxy-4-phenyl-4-pentenoate wasobtained in excellent chemical yield (94 %) with high enantioselectivity (70 %). Other¦Á-hydroxy esters can also be obtained in high chemical yields and enantioselectitiesthrough the glyoxylate-ene reactions of alkenes with glyoxylates catalyzed by 1b in[bmim][PF6]. Moreover, the ionic liquid [bmim][PF6] which contained the palladium(II)complex could be recycled and reused several times without significant loss of the catalyticactivity. %K Ionic liquid %K glyoxylate-ene reaction %K palladium %K chiral %K 1-n-butyl-3-methyl- imidazolium hexafluorophosphate %U http://www.mdpi.com/1422-0067/8/6/553