%0 Journal Article
%T SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity
%A Kristin Leinhart
%A Mark Brown
%J Genes
%D 2011
%I MDPI AG
%R 10.3390/genes2010210
%X The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of£¿lysine methyltransferases and their role in transcriptional regulation, epigenetics, and£¿tumorigenesis.
%K SET
%K MYND
%K Smyd1
%K Smyd2
%K Smyd3
%K transcriptional regulation
%K chromatin modifications
%K epigenetics
%K tumorigenesis
%U http://www.mdpi.com/2073-4425/2/1/210