%0 Journal Article
%T Chiral ¦Â-Amino Alcohols as Ligands for the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of N-Phosphinyl Ketimines
%A ¨®scar Pablo
%A David Guijarro
%A Miguel Yus
%J Applied Sciences
%D 2012
%I MDPI AG
%R 10.3390/app2010001
%X Some chiral ¦Â-amino alcohols have been evaluated as potential ligands for the ruthenium-catalyzed asymmetric transfer hydrogenation (ATH) of N-phosphinyl ketimines in isopropyl alcohol. The ruthenium complex prepared from [RuCl 2( p-cymene)] 2 and (1 S,2 R)-1-amino-2-indanol has shown to be an efficient catalyst for the ATH of several N-(diphenylphosphinyl)imines, affording the reduction products in very good isolated yields and enantiomeric excesses up to 82%. The inherent rigidity of the indane ring system present in the ligand seems to be very important to achieve good enantioselectivities.
%K N-(diphenylphosphinyl)imine
%K asymmetric transfer hydrogenation
%K ruthenium catalyst
%K ¦Â-amino alcohol
%K isopropyl alcohol
%U http://www.mdpi.com/2076-3417/2/1/1