%0 Journal Article
%T Microfluidic cell culture array chip for drug screening assays<br>用于药物筛选的微流控细胞阵列芯片
%A Yunhuan Zheng
%A Jianzhang Wu
%A Jianbo Shao
%A Qinghui Jin
%A Jianlong Zhao
%A <br>郑允焕
%A 吴建璋
%A 邵建波
%A 金庆辉
%A 赵建龙
%J 生物工程学报
%D 2009
%I 
%X We developed a novel microfluidic cell chip, which enabled drug delivery, fluid control and cell co-culture. The device consisted of an array of 6×6 cell culture chambers, a drug gradient generator and fluidic control valves. Micro-dam structures of the chambers were able to trap cells while loading and drug gradient network generated drug gradient of 6 different concentrations. Also we applied hydraulic valves to control the microfluid and simulate the microenvironment of cells. We had investigated the viability of co-culturing cells in the chip and the ability for drug screening. This microfluidic cell chip has the potential in cell-based research of high throughput drug screening.
%K microfluidic chip
%K drug screening
%K C-shaped dam
%K micro-valves
%K drug gradient generator
%K cell co-culture<br>微流控芯片
%K 药物筛选
%K C型坝结构
%K 微阀
%K 药物浓度梯度
%K 细胞共培养
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=09B4271D71AC83672457103065936EBC&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=94C357A881DFC066&sid=EEAFC972BAD75B1F&eid=A1BB529A18D3A83E&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=1&reference_num=12