%0 Journal Article
%T Polyfunctional T-Cell Responses Are Disrupted by the Ovarian Cancer Ascites Environment and Only Partially Restored by Clinically Relevant Cytokines
%A Eric Tran
%A Julie S. Nielsen
%A Darin A. Wick
%A Alvin V. Ng
%A Lisa D. S. Johnson
%A Nancy J. Nesslinger
%A Elissa McMurtrie
%A John R. Webb
%A Brad H. Nelson
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0015625
%X Host T-cell responses are associated with favorable outcomes in epithelial ovarian cancer (EOC), but it remains unclear how best to promote these responses in patients. Toward this goal, we evaluated a panel of clinically relevant cytokines for the ability to enhance multiple T-cell effector functions (polyfunctionality) in the native tumor environment.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015625