%0 Journal Article
%T NutriSim  Diminishes an Endotoxin-stimulated Proinflammatory Cytokine Production
%J American Journal of Biochemistry
%@ 2163-3029
%D 2012
%I 
%R 10.5923/j.ajb.20120206.01
%X Lipopolysaccharide, a main component of Gram-negative bacterial endotoxin is the leading cause of sepsis or endotoxic shock. This condition generates tissue hypoperfusion and leads to a state of acute metabolic-circulatory dysfunction and multiorgan systemic failure which contributes to amplify the inflammatory response and resulting in the release of pro-inflammatory cytokines (TNF-¦Á, IL-1 and IL-6). The effect of NutriSim  on serum pro-inflammatory cytokine concentrations were investigated in lipopolysaccharide-treated male Wistar rats. Animals were randomized into five groups: control groups receiving a single intraperitoneal injection of physiologic saline solution or NutriSim  (10¦Ìl), respectively; LPS (20 mg/Kg, i.p.); NutriSim  treatment 15 min before or after LPS in the same aforementioned dose. The results showed that a single dose of NutriSim  prior or before the endotoxic insult diminishes significantly the production of serum TNF-¦Á, IL-1 and IL-6. Therefore NutriSim  can modulate an inflammatory response in experimental model of endotoxic shock.
%K Nutrisim
%K TNF-¦Á
%K IL-1
%K IL-6
%K Endotoxic Shock
%K Lipopolysaccharide
%U http://article.sapub.org/10.5923.j.ajb.20120206.01.html