%0 Journal Article
%T Treatment of patients with keratoconjunctivitis sicca with Optive : results of a multicenter, open-label observational study in Germany
%A Thomas Kaercher
%A Patricia Buchholz
%A Friedemann Kimmich
%J Clinical Ophthalmology
%D 2009
%I 
%R http://dx.doi.org/10.2147/OPTH.S4501
%X eatment of patients with keratoconjunctivitis sicca with Optive : results of a multicenter, open-label observational study in Germany Original Research (5477) Total Article Views Authors: Thomas Kaercher, Patricia Buchholz, Friedemann Kimmich Published Date November 2008 Volume 2009:3 Pages 33 - 39 DOI: http://dx.doi.org/10.2147/OPTH.S4501 Thomas Kaercher1, Patricia Buchholz2, Friedemann Kimmich3 1Augenarztpraxis, Heidelberg, Germany; 2Allergan Europe, Ettlingen, Germany; 3Eyecons, Pfinztal, Germany Objective: To evaluate the efficacy and tolerability of OptiveTM, a new dry eye product containing sodium carboxymethylcellulose (0.5%) and glycerol (0.9%), in patients with keratoconjunctivitis sicca (KCS). Methods: This was a non-interventional and observational study including patients with dry eye who required a change of medication or were na ve to dry eye treatment (N = 5,277). Disease severity, tear break-up time (TBUT), tolerability, and change in clinical symptoms were recorded at baseline and at final visit (2 to 4 weeks after first treatment). Results: The severity of KCS was mild in 18.6%, moderate in 59.9%, and severe in 21.5% of patients based on physicians¡¯ assessment. TBUT was measured in 4,338 patients before switching to or initiating therapy with Optive and at final visit. Baseline measurement of mean TBUT was 7.7 ¡À 3.9 seconds. This value increased to 10.0 ¡À 4.7 seconds at final visit. Most patients (85.4%) reported improvement in local comfort. The majority (75.1%) of patients felt an improvement in symptoms after changing their treatment. Two percent of patients reported adverse events, and 0.4% were treatment-related. Conclusions: Optive was well tolerated and improved the symptoms of dry eye after 2 to 4 weeks.
%K keratoconjunctivitis sicca
%K dry eye
%K sodium carboxymethylcellulose
%K glycerol
%K OptiveTM
%U https://www.dovepress.com/treatment-of-patients-with-keratoconjunctivitis-sicca-with-optivetrade-peer-reviewed-article-OPTH