%0 Journal Article
%T In vivo laser confocal microscopy findings in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy
%A Kobayashi A
%A Yokogawa H
%A Sugiyama K
%J Clinical Ophthalmology
%D 2012
%I 
%R http://dx.doi.org/10.2147/OPTH.S34196
%X vivo laser confocal microscopy findings in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy Case Series (1491) Total Article Views Authors: Kobayashi A, Yokogawa H, Sugiyama K Published Date July 2012 Volume 2012:6 Pages 1187 - 1190 DOI: http://dx.doi.org/10.2147/OPTH.S34196 Received: 24 May 2012 Accepted: 12 June 2012 Published: 27 July 2012 Akira Kobayashi, Hideaki Yokogawa, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Background: The purpose of this study was to investigate pathological changes of the corneal cell layer in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy by in vivo laser corneal confocal microscopy. Methods: Two patients were evaluated using a cornea-specific in vivo laser scanning confocal microscope (Heidelberg Retina Tomograph 2 Rostock Cornea Module, HRT 2-RCM). The affected corneal areas of both patients were examined. Image analysis was performed to identify corneal epithelial and stromal deposits correlated with this dystrophy. Results: Variously shaped (linear, multilaminar, curvilinear, ring-shape, geographic) highly reflective materials were observed in the ˇ°mapˇ± area, mainly in the basal epithelial cell layer. In ˇ°fingerprintˇ± lesions, multiple linear and curvilinear hyporeflective lines were observed. Additionally, in the affected corneas, infiltration of possible Langerhans cells and other inflammatory cells was observed as highly reflective Langerhans cell-like or dot images. Finally, needle-shaped materials were observed in one patient. Conclusion: HRT 2-RCM laser confocal microscopy is capable of identifying corneal microstructural changes related to map-dot-fingerprint corneal dystrophy in vivo. The technique may be useful in elucidating the pathogenesis and natural course of map-dot-fingerprint corneal dystrophy and other similar basement membrane abnormalities.
%K cornea
%K confocal microscopy
%K map-dot-fingerprint dystrophy
%K epithelial basement membrane dystrophy
%K Heidelberg Retina Tomograph 2 Rostock Cornea Module (HRT 2-RCM)
%U https://www.dovepress.com/in-vivo-laser-confocal-microscopy-findings-in-patients-with-map-dot-fi-peer-reviewed-article-OPTH