%0 Journal Article
%T The Role of Histone H4 Biotinylation in the Structure of Nucleosomes
%A Nina A. Filenko
%A Carol Kolar
%A John T. West
%A S. Abbie Smith
%A Yousef I. Hassan
%A Gloria E. O. Borgstahl
%A Janos Zempleni
%A Yuri L. Lyubchenko
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0016299
%X Post-translational modifications of histones play important roles in regulating nucleosome structure and gene transcription. It has been shown that biotinylation of histone H4 at lysine-12 in histone H4 (K12Bio-H4) is associated with repression of a number of genes. We hypothesized that biotinylation modifies the physical structure of nucleosomes, and that biotin-induced conformational changes contribute to gene silencing associated with histone biotinylation.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016299