%0 Journal Article
%T INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months
%A Ann Chen Wu
%A Matthew W. Gillman
%A Elsie M. Taveras and Augusto A. Litonjua
%J Clinical Medicine Insights: Pediatrics
%D 2012
%I 
%X Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11¨C60 years.1  To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.
%U http://www.la-press.com/insig2-is-associated-with-lower-gain-in-weight-for-length-between-birt-article-a1330