%0 Journal Article
%T Influence of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Socioemotional Behaviors in Offspring Rats
%A Anh T.N. Nguyen
%A Muneko Nishijo
%A Etsuro Hori
%A Nui M. Nguyen
%A Tai T. Pham
%A Kohji Fukunaga
%A Hideaki Nakagawa
%A Anh H. Tran
%A Hisao Nishijo
%J Environmental Health Insights
%D 2012
%I 
%R 10.4137/EHI.S10346
%X Effects of dioxins on cognitive functions were reported in previous studies conducted in humans and animals. In the present study, we investigated the influence of dioxin exposure during pregnancy on social interaction and on the activity of offspring, which are related to neurodevelopmental disturbances. In addition, we analyzed neurochemical alterations of the limbic system of rat brains to suggest one mechanism of dioxin effects on brain function. We believe that this manuscript is suitable for publication in "Environmental Health Insights" because it provides an interesting topic for a wide global audience. To clarify the relationships between maternal dioxin exposure and socioemotional functions of rat offspring, dams were given TCDD (1.0 ¦Ìg/kg) on gestational day 15. Social interactions and forced swimming time were compared between TCDD-exposed and control offspring in each gender. Frequency and duration of locomotion were higher, and durations per one behavior of proximity and social contact were significantly lower in the exposed males, while only the duration of proximity was lower in the exposed females. Forced swimming time on the first day was significantly longer in the exposed males. In the limbic system of the rat brain, the levels and/or activity of CaMKII¦Á were decreased in males and were increased in females in the exposed offspring. These results suggest that prenatal TCDD exposure induces hyperactivity and socioemotional deficits, particularly in the male offspring due to alterations in CaMKII¦Á activity in the limbic system of the brain.
%U http://www.la-press.com/influence-of-maternal-exposure-to-2378-tetrachlorodibenzo-p-dioxin-on--article-a3562