%0 Journal Article %T Polymorphism Study of the Insulin Receptor Substrate IRS1 and IRS2 Genes Associated with Type 2 Diabetes in Ethnic Groups of Djerba Island %A T. Baroudi Ouederni %A J. Sanchez-Corona %A A. Fadiel %A T. Johnson-Scalise %A A. Beeghly-Fadiel %A S. Flores Martinez %A H. Ben Maiz %A H. Kammoun Abid %A H. Aounallah Skhiri %A A. Benammar-Elgaaied and A. Hamza %J Clinical Medicine Reviews in Vascular Health %D 2012 %I %R 10.4137/CMRVH.S3378 %X Aim: We aimed to evaluate the influence of the Gly972 Arg and Ala513Pro variants of the insulin receptor substrate1 gene (IRS1) and the Gly1057 Asp variant in IRS on type 2 diabetes mellitus (T2DM) in Arab and Berber men and women from Djerba Island, Tunisia. Methods: Genotypes, allelic and genotypic frequencies were studied. The amplified products were analyzed by Restriction Fragment Length Polymorphism (RFLP) methods by comparing T2DM with healthy controls from the same ethnicity. Results: No differences in genotype or allelic frequencies were found between T2DM and healthy controls in either Arab or Berber ethnic groups. Conclusion: The Gly972 Arg and Ala513Pro variants in IRS1 and Gly1057 Asp in IRS2 polymorphisms are not associated with T2DM in the Arab or Berber populations of Djerba Island %U http://www.la-press.com/polymorphism-study-of-the-insulin-receptor-substrate-irs1-and-irs2-gen-article-a2220