%0 Journal Article %T Characterization of Single Nucleotide Polymorphisms in 13 Members of the ABC Drug Transporter Genes in Three Different Populations %A Zihua Wang %A Samuel S. Chong and Caroline G.L. Lee %J The Open Pharmacology Journal %D 2007 %I %R 10.2174/1874143600701010001] %X To evaluate the usefulness of the two public databases, HapMap and Perlegen, in facilitating studies associating polymorphisms in these genes with drug response, we examined 111 single-nucleotide-polymorphisms from 13 ABCtransporter genes in Singaporean-Chinese, European-Americans and African-Americans. We found that genotype data from the HapMap/Perlegen databases are generally transferable to different sampling of the same population and to similar populations residing elsewhere. However, not all ABC-transporter family genes are amenable to SNP-tagging due to the low tagging-efficiency of low-LD genes resulting in negligible cost-savings. Hence, alternative approaches may have to be explored for low-LD ABC genes. %U http://www.benthamscience.com/open/topharmj/articles/V001/1TOPHARMJ.htm