%0 Journal Article
%T Modulation of neuronal activity of cerebellar fastigial nucleus by locus coeruleus stimulation in the rat
%A Wang Tao
%A Wang Jianjun
%A Cheng Hong
%A Li Hongzhao
%A Yu Qixiang
%J Chinese Science Bulletin
%@ 1861-9541
%D 1998
%I 
%R 10.1007/BF02884618
%X The effects of stimulating locus coeruleus (LC) on neuronal activity of cerebellar fastigii nucleus (FN) was investigated. Stimulation of LC elicited inhibitory, excitatory and biphasic (inhibition-excitation) responses from FN cells. The majority of responsive cells showed an inhibitory response with a latency of less than 10 ms. Injection of a adrenoreceptor antagonists phentolamine (iV) could block the inhibitory response of FN cells to the LC stimulation, but propranolol (IV), a ¦Â adrenoreceptor antagonist, could not. These results suggest that LC-cerebellar noradrenergic afferent fibers may be involved in the cerebellar sensorimotor integration process by exerting their modulatory action on the cerebellar nuclear cells¡¯ activities.
%K locus coeruleus
%K cerebellar fastigial nucleus
%K coearuleo-cerebellar pathway
%K noradrenergic fibers
%U http://link.springer.com/article/10.1007/BF02884618