%0 Journal Article
%T Association of ¦Â-fibrinogen gene  148C/T and  455G/A polymorphisms and coronary artery disease in Chinese population: A Meta analysis
%A XiaoChao Chen
%A MingTong Xu
%A LiZi Jin
%A Jian Chen
%A WeiQing Chen
%J Science China Life Sciences
%@ 1869-1889
%D 2008
%I 
%R 10.1007/s11427-008-0102-0
%X The purpose of our study was to evaluate the correlation between the ¦Â-fibrinogen gene  148C/T and  455G/A polymorphisms and susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases and 1234 controls) involved the  148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the  455G/A polymorphism. No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in  148T allele carriers compared to the  148C/C wild-type homozygotes was 1.31 (95%CI: 0.94¨C1.84, P=0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in  455A allele carriers compared to the  455G/G wild-type homozygotes was 1.75 (95%CI: 1.24¨C2.46, P=0.001). Our results suggest the absence of an association between the ¦Â-fibrinogen gene  148C/T polymorphism and susceptibility to coronary artery disease and the possibility that  455G/A polymorphism (in particular, allele A) increases susceptibility to this disease in the Chinese population.
%K ¦Â-fibrinogen
%K gene polymorphism
%K coronary artery disease
%K myocardial infarction
%K Meta-analysis
%U http://link.springer.com/article/10.1007/s11427-008-0102-0