%0 Journal Article
%T Study of ¦Â-amyloid adsorption and aggregation on graphite by STM and AFM
%A Zhigang Wang
%A Lijun Wan
%A Chunqing Zhou
%A Xiaohong Fang
%A Chen Wang
%A Chunli Bai
%J Chinese Science Bulletin
%@ 1861-9541
%D 2003
%I 
%R 10.1007/BF03183245
%X The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of ¦Â-amyloid(1¨C42)(A¦Â42) on the hydrophobic graphite surface. It was found that A¦Â42 were preferentially adsorbed on graphite defects such as the edges. A¦Â42 peptides self-assembled into intermediate protofibrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation process of ¦Â-amyloid.
%K sanning tunneling microscopy
%K atomic force microscopy
%K ¦Â-amyloid
%K fibrillization
%U http://link.springer.com/article/10.1007/BF03183245