%0 Journal Article
%T IFN¦Ã Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia
%A Helena del Corral
%A Sara C. Par¨ªs
%A Nancy D. Mar¨ªn
%A Diana M. Mar¨ªn
%A Lucelly L¨®pez
%A Hanna M. Henao
%A Teresita Mart¨ªnez
%A Liliana Villa
%A Luis F. Barrera
%A Blanca L. Ortiz
%A Mar¨ªa E. Ram¨ªrez
%A Carlos J. Montes
%A Mar¨ªa C. Oquendo
%A Lisandra M. Arango
%A Felipe Ria£¿o
%A Carlos Aguirre
%A Alberto Bustamante
%A John T. Belisle
%A Karen Dobos
%A Gloria I. Mej¨ªa
%A Margarita R. Giraldo
%A Patrick J. Brennan
%A Jaime Robledo
%A Mar¨ªa P. Arbel¨¢ez
%A Carlos A. Rojas
%A Luis F. Garc¨ªa
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0008257
%X Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) using specific M. tuberculosis antigens provide an alternative to tuberculin skin testing (TST) for infection detection. Additionally, the levels of IFN¦Ã produced in response to these antigens may have prognostic value. We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFN¦Ã levels in HHCs correlate with tuberculosis development.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008257