%0 Journal Article
%T Avalia£¿£¿o da regenera£¿£¿o hep¨¢tica com modula£¿£¿o pelo pr¨¦-condicionamento isqu¨ºmico ap¨®s isquemia e reperfus£¿o e hepatectomia parcial
%A Salom£¿o
%A Laura Sampaio
%A Young
%A Silvia Barbosa
%A Galhardo
%A Maria Aparecida
%A Pereira
%A Leandro Alves
%A Pires
%A Andr¨¦a Rodrigues Cordovil
%A Boaventura
%A Gilson Teles
%A Ferreira
%A Ana Maria Reis
%A Martinho
%A Jos¨¦ Manoel
%J Revista do Col¨¦gio Brasileiro de Cirurgi£¿es
%D 2012
%I Col¨¦gio Brasileiro de Cirurgi?es
%R 10.1590/S0100-69912012000300009
%X objective: to evaluate liver regeneration modulated by ischemic preconditioning after ischemia, reperfusion and partial hepatectomy. methods: we used 24 wistar rats of 12 weeks of age, which were randomly assigned into four groups: control (sham), hepatectomy (hep), ischemia and reperfusion (irg) and ischemic preconditioning (srg). analyses were made on liver enzymes alt and ast, assessment of regeneration through the initial and final weight of the liver and the proliferation of hepatocytes by immunohistochemical analysis with proliferating cell nuclear antigen (pcna). results: in all groups there was liver regeneration, with no statistically significant difference between them. there were significant differences in alt and ast between groups hep and sham, pre and gir, gir and sham and pre and sham (p <0.05). there were also significant differences in the pcna labeling of the sham group as compared to other groups (p <0.05). conclusion: the ischemic preconditioning decreased liver injury, but did not influence the regeneration up to 48 hours.
%K hepatic regeneration
%K ischemic preconditioning
%K ischemia
%K reperfusion
%K hepatectomy.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-69912012000300009&lng=en&nrm=iso&tlng=en