%0 Journal Article
%T Optimal Lead Time for Dengue Forecast
%A Yien Ling Hii
%A Joacim Rocklˋv
%A Stig Wall
%A Lee Ching Ng
%A Choon Siang Tang
%A Nawi Ng
%J PLOS Neglected Tropical Diseases
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pntd.0001848
%X Background A dengue early warning system aims to prevent a dengue outbreak by providing an accurate prediction of a rise in dengue cases and sufficient time to allow timely decisions and preventive measures to be taken by local authorities. This study seeks to identify the optimal lead time for warning of dengue cases in Singapore given the duration required by a local authority to curb an outbreak. Methodology and Findings We developed a Poisson regression model to analyze relative risks of dengue cases as functions of weekly mean temperature and cumulative rainfall with lag times of 1每5 months using spline functions. We examined the duration of vector control and cluster management in dengue clusters > = 10 cases from 2000 to 2010 and used the information as an indicative window of the time required to mitigate an outbreak. Finally, we assessed the gap between forecast and successful control to determine the optimal timing for issuing an early warning in the study area. Our findings show that increasing weekly mean temperature and cumulative rainfall precede risks of increasing dengue cases by 4每20 and 8每20 weeks, respectively. These lag times provided a forecast window of 1每5 months based on the observed weather data. Based on previous vector control operations, the time needed to curb dengue outbreaks ranged from 1每3 months with a median duration of 2 months. Thus, a dengue early warning forecast given 3 months ahead of the onset of a probable epidemic would give local authorities sufficient time to mitigate an outbreak. Conclusions Optimal timing of a dengue forecast increases the functional value of an early warning system and enhances cost-effectiveness of vector control operations in response to forecasted risks. We emphasize the importance of considering the forecast-mitigation gaps in respective study areas when developing a dengue forecasting model.
%U http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001848