%0 Journal Article %T S¨ªntese e determina£¿£¿o da atividade antimicrobiana de derivados 5-nitro-2-tiofilid¨ºnicos frente a Staphylococcus aureus multi-resistente %A Masunari %A Andrea %A Tavares %A Leoberto Costa %J Revista Brasileira de Ci¨ºncias Farmac¨ºuticas %D 2006 %I Scientific Electronic Library Online %R 10.1590/S1516-93322006000300016 %X infection diseases caused by methicillin-resistant staphylococcus aureus have been an increasing problem worldwide presenting significant morbidity and mortality rates. thus, fourteen benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazides were designed, synthesized and tested against standard (atcc 25923) and multidrug-resistant strains of staphylococcus aureus. all compounds exhibited significant bacteriostatic activity and, in such cases, also bactericidal activity, especially the p-coch3 derivative with mic = 0.14 mg/ml. the results have demonstrated the potential of synthesized compounds as alternative to the development of selective antimicrobial agents. %K staphylococcus aureus %K synthesis %K mic %K nifuroxazide %K multidrug-resistance. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-93322006000300016&lng=en&nrm=iso&tlng=en