Stroke is the most common cause of seizures, symptomatic epilepsy, and status epilepticus in elderly. Symptomatic stroke-related seizures symptoms are dependent on lesions topography. All types of focal seizures can be observed. Many clinical studies make a distinction between early (within 7 to 14 days of stroke onset) and late (beyond 14 days of stroke onset) seizures based on presumed physiopathological differences. The diagnosis of a seizure during the acute phase of a stroke can be difficult in the absence of a witness when there are disorders of vigilance and speech. The use of antiepileptic drugs is discussed in all cases. New antiepileptic drugs appear to be most appropriate. The aim of this study is to present an overview of the epidemiological, clinical and therapeutic features of vascular epilepsy based on meta-analyses and the more recently published expert recommendations.
Cite this paper
Bnouhanna, W. , Satté, A. , Mounach, J. and Ouhabi, H. (2019). Overview of Post-Stroke Epilepsy. Open Access Library Journal, 6, e5705. doi: http://dx.doi.org/10.4236/oalib.1105705.
Van Tuijl, J., van Raaka, E.P.M., de Kroma, M.C.T.F.M., Loddera, J. and Aldenkamp, A.P. (2011) Early Treatment after Stroke for the Prevention of Late Epileptic Seizures: A Report on the Problems Performing a Randomised Placebo-Controlled Double-Blind Trial Aimed at Anti-Epileptogenesis. Seizure, 20, 285-291. https://doi.org/10.1016/j.seizure.2010.12.012
Chen, T.C., Chen, Y., Cheng, P. and Lai, C. (2012) The Incidence Rate of Post-Stroke Epilepsy: A 5-Year Follow-Up Study in Taiwan. Epilepsy Research, 102, 188-194. https://doi.org/10.1016/j.eplepsyres.2012.06.003
Sun, D., Sombati, S., Blair, R. and DeLorenzo, R. (2004) Long-Lasting Alterations in Neuronal Calcium Homeostasis in an in Vitro Model of Stroke-Induced Epilepsy. Cell Calcium, 35, 155-163. https://doi.org/10.1016/j.ceca.2003.09.003
De Reuck, J., Nagya, E. and Van Maele, G. (2007) Seizures and Epilepsy in Patients with Lacunar Strokes. Journal of the Neurological Sciences, 263, 75-78. https://doi.org/10.1016/j.jns.2007.06.004
Garrett, M., et al. (2009) Pre-dictors of Seizure Onset after Intracerebral Hemorrhage and the Role of Long-Term Antiepileptic Therapy. Journal of Critical Care, 24, 335-339. https://doi.org/10.1016/j.jcrc.2008.10.015
Kammersgaard Lars, P. and Olsen, T.S. (2005) Post Stroke Epilepsy in the Copenhagen Stroke Study: Incidence and Pre-dictors. Journal of Stroke and Cerebrovascular Diseases, 14, 210-214. https://doi.org/10.1016/j.jstrokecerebrovasdis.2005.07.001
Strzelczyk, A., Haag, A., Raupach, H., Herrendorf, G., Hamer, H.M. and Rosenow, F. (2010) Prospective Evaluation of a Post-Stroke Epilepsy Risk Scale. Journal of Neurology, 257, 1322-1326. https://doi.org/10.1007/s00415-010-5520-9
Leone, M., et al. (2009) Risk Factors for a First Epileptic Seizure after Stroke: A Case Control Study. Journal of the Neurological Sciences, 277, 138-142. https://doi.org/10.1016/j.jns.2008.11.004
Conrad, J., Paw-lowski, M., Dogan, M., Kovac, S. Ritter, M.A. and Evers, S. (2013) Seizures after Cere-brovascular Events: Risk Factors and Clinical Features. Seizure, 22, 275-282. https://doi.org/10.1016/j.seizure.2013.01.014
Chun-Ming, C., Tsoi, T.-H., Au-Yeung, M. and Suk-Yan Tang, A. (2003) Epileptic Seizure after Stroke in Chinese Patients. Journal of Neurology, 250, 839-843. https://doi.org/10.1007/s00415-003-1091-3
Okuda, S., Takano, S., Ueno, M., Hamaguchi, H. and Kanda, F. (2012) Clinical Features of Late-onset Poststroke Seizures. Journal of Stroke and Cerebrovascular Diseases, 21, 583-586. https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.01.006
DeReuck, J., De Groote, L. and Van Maele, G. (2008) Single Seizure and Epilepsy in Patients with a Cerebral Territorial Infarct. Journal of Neuroscience, 271, 127-130. https://doi.org/10.1016/j.jns.2008.04.005
Ruiz-Gimenez, J., Sánchez-álvarez, J.C., Ca？adillas-Hidalgo, F. and Serrano-Castro, P.J. (2010) Antiepi-leptic Treatment in Patients with Epilepsy and Other Comorbidities. Seizure, 19, 375-382. https://doi.org/10.1016/j.seizure.2010.05.008
Belcastro, V., Pier-guidi, L. and Tambasco, N. (2011) Levetiracetam in Brain Ischemia: Clinical Implica-tions in Neuroprotection and Prevention of Post-Stroke Epilepsy. Brain & Develop-ment, 33, 289-293. https://doi.org/10.1016/j.braindev.2010.06.008
Holtkamp, M., et al. (2017) European Stroke Organisation Guidelines for the Management of Post-Stroke Seizures and Epilepsy. European Stroke Journal, 2, 103-115.
Werhahn, K., Klimpe, S., Balkaya, S., Trinka, E. and Kr？mer, G. (2011) The Safety and Efficacy of Add-on Levetiracetam in Elderly Patients with Focal Epilepsy: A One-Year Observa-tional Study. Seizure, 20, 305-311. https://doi.org/10.1016/j.seizure.2010.12.015
Belcastro, V., et al. (2013) Intravenous Lacosamide as Treatment Option in Post-Stroke Non Convulsive Status Epilepticus in the Elderly: A Proof-of-Concept, Observational Study. Seizure, 22, 905-907. https://doi.org/10.1016/j.seizure.2013.07.011
Chang, C.S., et al. (2014) Patients with Epilepsy Are at an Increased Risk of Subsequent Stroke: A Population-Based Cohort Study. Seizure, 23, 377-381. https://doi.org/10.1016/j.seizure.2014.02.007
Hamidou, B., et al. (2013) Prognostic Value of Early Epileptic Seizures on Mortality and Functional Disability in Acute Stroke: The Dijon Stroke Registry (1985-2010). Journal of Neurol-ogy, 260, 1043-1051. https://doi.org/10.1007/s00415-012-6756-3
