Deficiency in vitamin A is an evil in underdeveloped
countries where the minimum recommended intake is not achieved. This may have
long-term implications on the health of the population. For this reason, it
would be very useful to achieve an animal model where the different
implications of this deficiency can be observed. This could lead to the
formulation of future nutrition politics. The levels of retinoic acid and intermediary of the vitamin A pathway were studied;
The levels of retinoic acid and intermediary of the vitamin A pathway (CRBP-1
and RARα) were studied. There was a
decrease in the values of retinoic acid main indicator of deficiency of this
vitamin in serum, liver and mammary gland and variation in expression of CRBP-1
and RARα mRNA in mammary gland. This
model provides a tool for the study of the metabolism of vitamin A and its
effects in different organs and especially in virgin mammary gland, where a deficiency
is achieved despite being in a state of latency.
Cite this paper
Gomez, M. E. V. , Varas, S. and Gimenez, M. S. (2017). Model of Long-Term Vitamin A Deficiency in the Mammary Gland of Virgin Rats. Open Access Library Journal, 4, e3887. doi: http://dx.doi.org/10.4236/oalib.1103887.
Who (2009) Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995-2005. WHO Global Database on Vitamin A Deficiency. World Health Organization.
Stevens, G.A., Bennett, J.E., Hennocq, Q., Lu, Y., De-Regil, L.M., Rogers, L., Danaei, G., Li, G., et al. (2015) Trends and Mortality Effects of Vitamin A Deficiency in Children in 138 Low-Income and Middle-Income Countries between 1991 and 2013: A Pooled Analysis of Population-Based Surveys. The Lancet Global Health, 3, E528-E536.
https://doi.org/10.1016/S2214-109X(15)00039-X
Abrha, T., Girma, Y., Haile, K., Hailu, M. and Hailemariam, M. (2016) Prevalence and Associated Factors of Clinical Manifestations of Vitamin A Deficiency among Preschool Children in Asgede-Tsimbla Rural District, North Ethiopia, a Community Based Cross Sectional Study. Archives of Public Health, 74, 4.
https://doi.org/10.1186/s13690-016-0122-3
Klemm, R., Palmer, A., Greig, A., Engle-Stone, R. and Dalmiya, N. (2016) A Changing Landscape for Vitamin A Programs: Implications for Optimal Intervention Packages, Program Monitoring, and Safety. Food and Nutrition Bulletin, 1-12.
https://doi.org/10.1177/0379572116630481
Stephensen, C.B. (2001) Vitamin A, Infection, and Immune Function. The Annual Review of Nutrition, 21, 167-192.
https://doi.org/10.1146/annurev.nutr.21.1.167
Ivan, P., Uray, M.D., Dmitrovsky, E., Powel, H. and Brown, M.D. (2016) Retinoids and Rexinoids in Cancer Prevention: From Laboratory to Clinic. Seminars in Oncology, 43, 49-64.
https://doi.org/10.1053/j.seminoncol.2015.09.002
Gudas, L.J. (2012) Emerging Roles for Retinoids in Regeneration and Differentiation in Normal and Disease States. Biochimica et Biophysica Acta, 1821, 213-221.
https://doi.org/10.1016/j.bbalip.2011.08.002
WHO/UNICEF (1994) Indicators for Assessing Vitamin A Deficiency and Their Application in Monitoring and Evaluating Intervention Programmes. Review Version.
Tanumihardjo, S.A. (2011) Vitamin A: Biomarkers of Nutrition for Development. The American Journal of Clinical Nutrition, 94, 658S-665S.
https://doi.org/10.3945/ajcn.110.005777
Figueroa, D., Dantas, A. and Sales, M.C. (2013) Micronutrientes Deficiencias y Lineal de Crecimiento: Una Revisión Sistemática de Estudios Observacionales. [Micronutrients Deficiencies and Linear Growth: A Systematic Review of Observational Studies.] Noticias de Salud de Rio de Janeiro, 11, 18.
Cediel, G., Olivares, M., Lopez de Romana, D., La Frano, M., Brito, A. and Cori, H. (2015) Interpretation of Serum Retinol Data from Latin America and the Caribbean. Food and Nutrition Bulletin, 36, S98-S108.
https://doi.org/10.1177/0379572115585743
Dollé, P. and Niederreither, K. (2015) The Retinoids. Biology, Biochemistry, and Disease. Wiley Blackwell, United States of America.
https://doi.org/10.1002/9781118628003
Neeld, J.B. and Pearson, W.N. (1963) Macro-and Micro-Methods for the Determination of Serum Vitamin a Using Trifluoroacetic Acid. Journal of Nutrition, 79, 454-462.
Puissant, C. and Houdebine, L.M. (1990) An Improvement of the Single-Step Method of RNA 29 Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction. 30 Biotechniques, 8, 148-149.
West, K.P., LeClerq, S.C., Shrestha, S.R., Wu, L.S., Pradhan, E.K., Khartry, S.K., Kats, J., Adhikari, R. and Sommer, A. (1997) Effects of Vitamin A on Growth of Vitamin Deficient Children. Field Studies in Nepal. Journal of Nutrition, 127, 1957-1965.
Trasino, S.E., Tang, X.-H., Jessurun, J. and Gudas, L.J. (2015) Obesity Leads to Tissue, but not Serum Vitamin A Deficiency. Scientific Reports, 5, Article No. 15893.
https://doi.org/10.1038/srep15893
Berry, D.C. and Noy, N. (2009) All-Trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor β/δ and Retinoic Acid Receptor. Molecular and Cellular Biology, 29, 3286-3296.
https://doi.org/10.1128/MCB.01742-08
Goodman, D.S. and Blaner, W.S. (1984) Biosynthesis, Absorption, and Hepatic Metabolism of Retinol. In: Sporn, M.B., Roberts, A.B. and Goodman, D.S., Eds., The Retinoids, Vol. 2, Academic Press, New York, 1-39.
Vogel, S., Gamble, M.V. and Blaner, W.S. (2010) Retinoid Uptake, Metabolism and Transport. In: Nau, H. and Blaner, W.S., Eds., The Handbook of Experimental Pharmacology, The Retinoids, Springer Verlag, Heidelberg, 31-96.
Maden, M. and Hind, M. (2003) Retinoic Acid, a Regeneration-Inducing Molecule. Developmental Dynamics, 226, 237-244.
https://doi.org/10.1002/dvdy.10222
Noy, N. (2010) Between Death and Survival: Retinoic Acid in Regulation of Apoptosis. Annual Review of Nutrition, 30, 201-217.
https://doi.org/10.1146/annurev.nutr.28.061807.155509
Wolbach, S.B. and Howe, P.R. (1978) Tissue Changes Following Deprivation of Fat-Soluble A Vitamin. Nutrition Reviews, 36, 16-19.
https://doi.org/10.1111/j.1753-4887.1978.tb03675.x
Xu, G., Redard, M., Gabbiani, G. and Neuville, P. (1997) Cellular Retinol-Binding Protein-1 Is Transiently Expressed in Granulation Tissue Fibroblasts and Differentially Expressed in Fibroblasts Cultured from Different Organs. American Journal of Pathology, 15, 1741-1749.
Kuppumbatti, Y.S., Bleiweiss, I.J., Mandeli, J.P., Waxman, S. and Mira, Y.L.R. (2000) Cellular Retinol-Binding Protein Expression and Breast Cancer. Journal of the National Cancer Institute, 92, 475-480.
https://doi.org/10.1093/jnci/92.6.475
Kim, K.H. and Griswold, M.D. (1990) The Regulation of Retinoic Acid Receptor mRNA Levels during Spermatogenesis. Molecular Endocrinology, 4, 1679-1688.
https://doi.org/10.1210/mend-4-11-1679
Haq, R., Pfahl, M. and Chytil, F. (1991) Retinoic Acid Affects the Expression of Nuclear Retinoic Acid Receptors in Tissues of Retinol-Deficient Rats. Proceedings of the National Academy of Sciences of the United States of America, 88, 8272-8276. https://doi.org/10.1073/pnas.88.18.8272
Verma, A.K., Shoemaker, A., Simsiman, R., Denning, M. and Zachman, R.D. (1992) Expression of Retinoic Acid Nuclear Receptors and Tissue Transglutaminase Is Altered in Various Tissues of Rats Fed a Vitamin A-Deficient Diet. Journal of Nutrition, 122, 2144-2152.
Napoli, J.A. (2000) Gene Knockout Corroborates the Integral Function of Cellular Retinol-Binding Protein in Retinoid Metabolism. Nutrition Review, 58, 230-241.
https://doi.org/10.1111/j.1753-4887.2000.tb01870.x
Nagy, N.E., Holven, K.B., Roos, N., Senoo, H., Kojima, N., Norum, K.B. and Blomhoff, R. (1997) Storage of Vitamin A in Extrahepatic Stellate Cells in Normal Rats. The Journal of Lipid Research, 38, 645-658.
Hussmann, M., Hoffmann, B., Stump, G.D., Chytil, F. and Pfahl, M. (1992) A Retinoic Acid Response Element from the Rat CRBP-1 Promoter Is Activated by an RAR/RXR Heterodimer. Biochemical and Biophysical Research Communications, 187, 1558-1564.
Xu, G., Bochaton-Piallat, M.L., Andreutti, D., Low, R.B., Gabbiani, G. and Neuville, P. (2001) Regulation of a-Smooth Muscle Actin and CRBP-1 Expression by Retinoic Acid and TGF-b in Cultured Fibroblasts. Journal of Cellular Physiology, 187, 315-325.
https://doi.org/10.1002/jcp.1078
Ghyselinck, N.B., Bavik, C., Sapin, V., Mark, M., Bonnier, D., Hindelang, C., Dierich, A., Nilsson, C.B., Hakansson, H., Sauvant, P., Azais-Braesco, V., Frasson, M., Picaud, S. and Chambon, P. (1999) Cellular Retinol Binding Protein I Is Essential for Vitamin A Homeostasis. The EMBO Journal, 18, 4903-4914.
https://doi.org/10.1093/emboj/18.18.4903
Kuppumbatti, Y.S., Rexer, B. and Nakajo, S. (2001) CRBP Suppresses Breast Cancer Cell Survival and Anchorage Independent Growth. Oncogene, 20, 7413-7419.
https://doi.org/10.1038/sj.onc.1204749
Cvetkovic, D., Williams, S.J. and Hamilton, T.C. (2003) Loss of Cellular Retinol-Binding Protein 1 Gene Expression in Microdissected Human Ovarian Cancer. Clinical Cancer Research, 9, 1013-1020.
Esteller, M., Guo, M., Moreno, V., Peinado, M.A., Capella, G., Galm, O., Baylin, S.B. and Herman, J.G. (2002) Hypermethylation-Associated Inactivation of the Cellular Retinol Binding Protein 1 Gene in Human Cancer. Cancer Research, 62, 5902-5905.
Piantedosi, R., Ghyselinck, N., Blaner, W.S. and Vogel, S. (2005) Cellular Retinol-Binding Protein Type III Is Needed for Retinoid Incorporation into Milk. The Journal of Biological Chemistry, 280, 24286-24292.
https://doi.org/10.1074/jbc.M503906200
Vogel, S., Mendelsohn, C.L., Mertz, J.R., Piantedosi, R., Waldburger, C., Gottesman, M.E. and Blaner, W.S. (2001) Characterization of a New Member of the Fatty Acid-Binding Protein Family that Binds All-Trans-Retinol. The Journal of Biological Chemistry, 276, 1353-1360.
https://doi.org/10.1074/jbc.M005118200
Pierzchalski, K., Yu, J., Norman, V. and Kane, M.A. (2013) Crbp1 Regulates Mammary Retinoic Acid Homeostasis and the Mammary Microenvironment. The FASEB Journal, 27, 1904-1916.
https://doi.org/10.1096/fj.12-219410
Orlandi, A., Ferlosio, A., Ciucci, A., Francesconi, A., Lifschitz-Mercer, B., Gabbiani, G., Spagnoli, G. and Czernobilsky, B. (2006) Cellular Retinol Binding Protein-1 Expression in Endometrial Hyperplasia and Carcinoma: Diagnostic and Possible Therapeutic Implications. Modern Pathology, 19, 797-803.
Doldo, E., Costanza, G., Ferlosio, A., Passeri, D., Bernardini, S., Scioli, M.G., Mazzaglia, D., Agostinelli, S., Del Bufalo, D., Czernobilsky, B. and Orlandi, A. (2014) CRBP-1 Expression in Ovarian Cancer: A Potential Therapeutic Target. Anticancer Research, 34, 3303-3312.
Altucci, L. and Gronemeyer, H. (2001) The Promise of Retinoids to Fight against Cancer. Nature Reviews Cancer, 1, 181-193.
https://doi.org/10.1038/35106036
Bryan, M., Pulte, E.D., Toomey, K.C., Pliner, L., Pavlick, A.C., Saunders, T. and Wieder, R.A. (2011) Pilot Phase II Trial of All-Trans Retinoic Acid (Vesanoid) and Paclitaxel (Taxol) in Patients with Recurrent or Metastatic Breast Cancer. Investigational New Drugs, 29, 1482-1487.
https://doi.org/10.1007/s10637-010-9478-3