Improvements in sanitation and the provision of
clean drinking water led to the elimination of typhoid fever from developed
countries in the beginning of the 20th century. However, Salmonella typhi and paratyphi remain a major source of morbidity and mortality in many
developing countries today. The dynamics of typhoid transmission are poorly
understood. In this study, we develop a novel mathematical model that captures
the role of both human to human interaction and human to environment
interaction in the transmission dynamics of typhoid fever. Our results have shown the feasible impact of different methods of typhoid control,
including vaccination, improved treatment strategies, and investment in clean
water and sanitation.
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