In sub-Saharan Africa, sexually transmitted
infections (STIs) and transfusiontransmissible infections (TTIs) are a public
health problem. Among them, we find the
syphilis that the recipient of blood might contract in the absence of serological
tests in the donor. The objective of this study was to determine the prevalence
and profile of the individual at risk for transmission of Treponema pallidum among blood donation candidates. This is a
single-center, retrospective and descriptive
cross-sectional study over a period from 2015 to 2016 at the Katele Health
Reference Center of Moba-Port in the Democratic Republic of Congo. The use of
Rapid Plasma Reagin (RPR) was required for the detection of anti-treponematosis
antibodies. The Epi Info 7.1 software was used to analyze the data at the
significant threshold of p 0.05. Of 752 blood donors tested, 62.8% were male
and the mean age was 30.3 ± 6.9 years with extremes ranging from 18 to 43
years. Family,
replacement donors were the most encountered (93.7%).
The seroprevalence of the Treponema
pallidum infection in blood donation candidates was 5.2%. Age (18 to 30
years) was significantly associated with the risk of transmission of syphilis
in the recipient of the blood (OR = 4.4; 95%
CI [1.86-10.24]; p-value 0.005). In 0.9% of cases, an
association with HIV was encountered. The risk of contracting
syphilis after transfusion remains high in our environment. It is mandatory to
continue to research the Treponema
pallidum in the serum of any blood donor. Education of the
population on prevention of sexually transmitted infections and transfusion
safety measures (especially during the donor screening phase) should be
strengthened.
Cite this paper
Kabemba, B. H. , Kasendue, E. P. , Shiku, M. A. , Kabingie, N. G. , Ngiele, M. D. , Kitengie, T. J. , Kahenga, K. J. and Pungue, K. J. (2017). Epidemiological Profile of Treponema pallidum Infection in Blood Donors Candidates at Moba, Tanganyika Province, Democratic Republic of Congo. Open Access Library Journal, 4, e3420. doi: http://dx.doi.org/10.4236/oalib.1103420.
OMS (2010) Dépistage des infections
transmissibles par transfusion dans les dons de sang: Recommandations. NLM-WB
356, Organisation
mondiale de la Santé, 2- 24.
Zhang, L., Jiao, S., Yang, Z., Xu, L., Liu, L., Feng, O., et
al. (2016)
Prevalence of Hepatitis
E Virus Infections among Blood Donors in Mainland China: A Meta-Ana- lysis.
Transfusion Dec 30.
Chattoraj,
A., Bhel, R. and
Kataria, V. (2008) Infectious Disease Markers in Blood Donors. Medical
Journal Armed Forces India, 64,
33-35. https://doi.org/10.1016/S0377-1237(08)80142-6
Pozzeto,
B. and
Garraud, O. (2016)
Nouveaux risques viraux en transfusion sanguine à l’horizon 2016. Transfusion Clinique et Biologique, 23,
20-27. https://doi.org/10.1016/j.tracli.2015.12.004
Kiire,
C.F.
(1996) The Epidemiology and Prophylaxis of Hepatitis B in Sub-Saharan Africa: A
View from Tropical and Subtropical Africa. Gut, 138,
S5-S12. https://doi.org/10.1136/gut.38.suppl_2.s5
Kabamba Nzaji, M. and
Kabyla Ilunga, B. (2013) Prévalence des marqueurs infectieux chez les donneurs de
sang en milieu rural. Cas de l’Hopital General de Reference de Kamina. Santé publique, 25, 213-217.
Nambei, W.S.,
Rawago-Mandjiza, D. and Gbangbangai, E. (2016)
Séroépidémiolo- gie du VIH, de la syphilis
et des virus des hépatites B et C chez les donneurs de sang à Bangui,
République Centre Africaine. Medecine et
Sante Tropicales, 26, 192-198.
Yang, S., Jiao, D., Liu, C., Lv, M., Li, S., Chen, Z., et al. (2016) Seroprevalence of Human Immunodeficiency
Virus, Hepatitis B and C Viruses, and Treponema
Pallidum Infections among Blood Donors at Shiyan, Central China. BMC Infectious Diseases, 16, 513. https://doi.org/10.1186/s12879-016-1845-z
Koanga Mogtomo, M.L.,
Louandji Fomekong, S., Fotso Kuate, H. and Ngono
Ngane, A. (2009) Détection des agents infectieux dans les banques de sang de
Douala (1995-2004). Santé, 19,
3-8.
Leibovici, V., Donchin,
M., Strauss-Liviatan,
N. and Shinar, E. (2014) Prevalence
and Incidence of Syphilis among Volunteer Blood Donors in Israel. Journal
of Blood Transfusion, 2014, Article ID 154048.
Kakisingi Ngama, C., Mukuku, O., Matanda Kapend, S., Manika Muteya, M., Kyabu
Kabila, V., Kasamba Ilunga,
E., et al. (2016) Profil épidémiologique et séropré-valence des donneurs de sang aux cliniques
universitaires de Lubumbashi, République
Démocratique du Congo. Pan African Medical Journal, 23, 175. http://www.panafrican-med-journal.com/content/article/23/175/full/
Sharma,
D.C., Rai, S., Bharat, S., Iyenger, S., Gupta, S. and
Jain, B. (2014) A 10 Years Comparative Study to Assess Trends in Seroprevalence
of Transfusion Transmitted Infections among Blood Donors at Gwalior, India. Open
Journal of Blood Diseases, 4,
24-32. https://doi.org/10.4236/ojbd.2014.42004
Ehoussou,
K., Tiembre, I., Benie, J., N’Doutable, M., Dagnan, S., Djeha, D., et al. (1997) Evaluation de la
séroprévalence de l’infection à VIH et VHB chez les donneurs de sang militaires à
Abidjan. Medecine d’Afrique Noire, 44, 620-624.
Batina,
A., Kabemba, S. and
Malengela, R. (2007) Marqueurs infectieux chez les donneurs de sang en
République Démocratique du Congo (RDC). Revue
Médicale de Bruxelles, 28, 145-149.
Rakotoniaina,
A.I., Randriamanantany, Z.A., Ranaivosoa, K.H.M., Andriambelo, V., Fortune, H.,
Rakoto Alson, O.A., et al. (2013) Séroprévalence du VIH, VHB, VHC et de Treponema pallidum chez les donneurs du
sang bénévoles au centre national de transfusion sanguine d’Antananarivo de
1992 à 2010. La Revue Médicale de Ma- dagascar, 3, 264-268.
Tayou Tagny, C. (2009) Le dépistage biologique de la
syphilis chez le donneur de sang d’Afrique subsaharienne: quelle stratégie? Transfusion
Clinique et Biologique, 16, 448-453. https://doi.org/10.1016/j.tracli.2009.07.004
Melese,
A. and
Tesfaye, W. (2016) Seroprevalence of Human Immunodeficiency Virus,
Hepatitis B Virus, Hepatitis C Virus, and Syphilis among Blood Donors at Jigjiga
Blood Bank, Eastern Ethiopia. Ethiopian
Journal of Health Sciences, 26, 153-160. https://doi.org/10.4314/ejhs.v26i2.9
Xu, S.,
Wang, Q., Zhang, W., Qiu, Z., Cui, J., Yan, W., et al. (2015) Seroprevalence of the Hepatitis B, Hepatitis C, and Human
Immunodeficiency Viruses and Treponema pallidum at the Beijing General
Hospital from 2010 to 2014: A Cross-Sectional Study. PLoS ONE, 10, e0140854.
Taylor, M.M., Nurse-Findlay, S., Zhang, X., Hedman, L.,
Kamb, M.L., Broutet, N., et al. (2016) Estimating Benzathine Penicillin Need for
the Treatment of Pregnant Women Diagnosed with Syphilis during Antenatal Care
in High-Morbidity Countries.PLoS ONE, 11, e0159483.
Tayou Tagny, C., Diarra, A., Rakia, Y., Hakizimana, M., Nguessan, A. and Mbenga, G. (2009) Le
centre de transfusion, les donneurs de sang et le sang donné dans les pays
d’Afrique francophone. Transfusion
Clinique et Biologique, 16, 431-438. https://doi.org/10.1016/j.tracli.2009.07.005
Mecky,
I.N.M., Pius, M.M. and
Eligius, F.L. (2006)
Seroprevalence of Human Immunodeficiency Virus, Hepatitis B and C Viruses and
Syphilis Infections among Blood Donors at the Muhimbili National Hospital in
Dar Es Salaam, Tanzania. BMC Public
Health, 6, 21. https://doi.org/10.1186/1471-2458-6-21
Nagalo,
B.M., Bisseye, C., Sanou, M., Kienou, K., Nebie, Y.K., Kiba, A., et al. (2012)
Seroprevalence and Incidence of Transfusion-Transmitted Infectious Diseases
among Blood Donors from Regional Blood Transfusion Centres in Burkina Faso,
West Africa. Tropical Medicine &
International Health, 17, 247-253.
Rasamindrakotroka,
A.J., Ramiandrisoa, A., Rahelimiarana, N., Radanielina, R., Kirsch, T. and
Rakotomanga, S. (1993) Donneurs de sang de la région tananarivienne:
Estimation de la Seroprevalence de la syphilis, de l’hépatite B et de l’infec- tion à
VIH. Médecine et Maladies infectieuses, 23,
40-41. https://doi.org/10.1016/S0399-077X(05)80999-0
Temmerman, M., Fonck, K.,
Bashir, F., Inion, I., Ndinya-Achola, J.O., Bwayo, J., et al. (1999)
Declining Syphilis Prevalence in Pregnant Women in Nairobi Since 1995: Another
Success Story in STDS. International Journal
of STD & AIDS, 10, 405-408. https://doi.org/10.1258/0956462991914339
Xie, D.-D., Li, J., Chen, J.-T., Eyi, U.M., Matesa,
R.A., Obono, M.M.O., et al. (2015)
Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus, Hepatitis C
Virus, and Treponema pallidum Infections among Blood Donors on Bioko Island, Equatorial Guinea. PLoS ONE, 10, e0139947. https://doi.org/10.1371/journal.pone.0139947
Rahlenbeck,
S.I., Yohannes, G., Molla, K., Reifen, R. and Assefa,
A. (1997) Infection
with HIV, Syphilis and Hepatitis B in Ethiopia: A Survey in Blood Donors. International Journal of STD & AIDS, 8,
261-264. https://doi.org/10.1258/0956462971919886
Olanrewaju, D.O., Isoa, E.M., Omoifo, V.O.,
Ikponmwen, O.D., Ehizogie, A.O., Otumu, O.S., et al. (2015) Quality of Care: Ensuring Patient Safety in
blood Transfusion in Irrua,
Edo State Nigeria. International Journal of Community Research, 4, 41-45.
Adjei, A.A., Kudzi, W., Armah, M., Adiku, T., Anoah, A.G. and Ansah, J. (2003)
Prevalence of Antibodies to Syphilis among Blood Donors in Accra, Ghana. Ja- panese Journal of Infectious Diseases, 56,
165-167.
Mayaki, Z., Dardenne, N., Kobo, R., Moutschen, M., Sondag,
D., Albert, A., et al. (2013) Séroprévalence des
marqueurs de l’infection chez les donneurs de sang à Niamey (Niger). Revue d’Epidémiologie et de Santé Publique, 61,
233-240. https://doi.org/10.1016/j.respe.2012.12.018
Mitchell,
K.M., Cox, A.P., Mabey, D., Tucker, J.D., Peeling, R.W. and
Vickerma, P. (2013)
The Impact of Syphilis Screening among Female Sex Workers in China: A Modelling
Study. PLoS ONE, 8,
e55622. https://doi.org/10.1371/journal.pone.0055622
Dean, A.G., Arner, T.G., Sangam, C.G., Sunki,
G.C., Friedman, R., Lantinga, M., et al. (2012)
EpiInfo, a Database and Statistics
Program for Public Health Professionals. Centers
for Disease Control and Prevention, Atlanta.
Kabemba
Bukasa, H., Kamuanya Wa Tshitanda, E., Kitengie Tshite, J., Atibu Bin Atibu, B.,
Ngiele Mposhi, D. and
Pungwe Kabiswe, J. (2017) Séroprévalence des infections par les virus de
l’immunodéficience humaine et des hépatites B et C chez les donneurs de sang au
service de sécurité transfusionnelle de Kalemie (République Démocratique du
Congo). Medecine d’Afrique Noire, 64, 47-56.
Senosy, S.A. (2015) Prevalence of HIV among Blood Donors
at Beni-Suef University Hospital Blood Bank, Egypt. The Journal of the Egyptian Public Health Association, 90, 157-160. https://doi.org/10.1097/01.EPX.0000475668.57932.29
Kabinda,
J.M., Miyanga, S.A., Misingi, P. and Ramarani, S.Y. (2014) Les hépatites B et C chez les
donneurs bénévoles de sang et non rémunérés à l’Est de la République
Démocratique du Congo. Transfusion
Clinique et Biologique, 21, 111-115. https://doi.org/10.1016/j.tracli.2014.04.001
Kra, O., N’Dri, N., Ehui,
E., Ouattara, B. and
Bissagnene, E. (2007)
Prévalence de l’Antigène HBS chez les donneurs de sang et au centre régional de
transfusion sanguine de Bouaké (Cote d’Ivoire) en 2001. Bulletin de la Société de Pathologie Exotique, 100,
127-129.
Diarra, A., Kouriba, B., Baby, M., Murphy, E. and Lefrere, J.-J.
(2009) HIV, HCV, HBV and Syphilis Rate of Positive Donations among Blood
Donations in Mali: Lower Rates among Volunteer Blood Donors. Transfusion Clinique et Biologique, 16,
444-447. https://doi.org/10.1016/j.tracli.2009.09.004
Sultan Ayesh, M.S., Faisal Muti, A.-H., Omar Saeed Ali, A., Abdullah Ebrahim Abdul-Alaziz,
A. and Huda Salman, B. (2012) Frequencies of HBV, HCV, HIV, and Syphilis Markers
among Blood Donors: A Hospital-Based Study in Hodeidah, Yemen. Tropical
Journal of Pharmaceutical Research, 11, 132-136.
Buseri,
F.I., Muhibi, M.A. and
Jeremiah, Z.A. (2009) Seroepidemiology of Transfusion Transmissible Infectious
Diseases among Blood Donors in Osogbo, South-West Nigeria. Blood Transfusion, 7,
293-299.
Attaullah, S., Khan, S. and
Khan, J. (2012)
Trend of Transfusion Transmitted Infections Frequency in Blood Donors: Provide
a Road Map for Its Prevention and Control. Journal of Translational Medicine, 10,
20. https://doi.org/10.1186/1479-5876-10-20
