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Association between Anthropometry, Dyslipidaemia and the Ten-Year Relative Risk of Cardiovascular Disease in Ghanaians with Type 2 Diabetes and Hypertension at the Battor Catholic Hospital

DOI: 10.4236/oalib.1103379, PP. 1-14

Subject Areas: Diabetes & Endocrinology

Keywords: Type 2 Diabetes, Hypertension, Cardiovascular Disease, Cardiovascular Risk, Framingham Risk Score, Dyslipidaemia

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Abstract

Disordered body fat distribution and plasma lipid levels promote atherosclerosis, a major risk factor for cardiovascular disease (CVD). The process of atherosclerosis is vigorous and rapid in diabetes and hypertension. This study sought to determine the relationship between anthropometric and dyslipidaemic parameters as well as ascertain using the Framingham percentage risk for heart disease, the ten-year relative risk of developing CVD among type 2 diabetes and hypertensive patients attending the Battor Catholic Hospital. This hospital-based case-control study involved 125 participants with hypertension, type 2 diabetes or both and 62 age-matched healthy individuals as controls. Socio-demographic data was captured using a semi-structured questionnaire; anthropometric and biochemical variables were obtained using standard methods. The anthropometric and atherogenic dyslipidaemic parameters of the case participants were found to be significantly higher compared to the controls. Among the case group, 49 (39.2%) were observed to have a high risk and 41 (32.8%) with a moderate risk of developing coronary heart disease in ten years. Among the control group, 11.3% presented with moderate risk with none scoring a high risk of developing coronary disease within ten years. The odds of developing coronary heart disease in ten years was 4.5 times higher among the case group with a higher female preponderance.

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Lokpo, S. Y. , Owiredu, W. K. B. A. , Osei-Yeboah, J. , Obirikorang, C. and Agyei-Frempong, M. T. (2017). Association between Anthropometry, Dyslipidaemia and the Ten-Year Relative Risk of Cardiovascular Disease in Ghanaians with Type 2 Diabetes and Hypertension at the Battor Catholic Hospital. Open Access Library Journal, 4, e3379. doi: http://dx.doi.org/10.4236/oalib.1103379.

References

[1]  De-Graft, A.A. (2007) Ghana’s Neglected Chronic Disease Epidemic: A Developmental Challenge. Ghana Medical Journal, 41, 154-159.
[2]  Bosu, W.K. (2010) Epidemic of Hypertension in Ghana: A Systematic Review. BMC Public Health, 10, 418. https://doi.org/10.1186/1471-2458-10-418
[3]  Halperin, R.O., Sesso, H.D., Ma, J., Buring, J.E., Stampfer, M.J. and Gaziano, J.M. (2006) Dyslipidemia and the Risk of Incident Hypertension in Men. Hypertension, 47, 45-50. https://doi.org/10.1161/01.HYP.0000196306.42418.0e
[4]  Deshmukh, P., Gupta, S., Dongre, A., et al. (2006) Relationship of Anthropometric Indicators with Blood Pressure Levels in Rural Wardha. Indian Journal of Medical Research, 123, 657.
[5]  Micah, F. and Nkum, B. (2012) Lipid Disorders in Hospital Attendants in Kumasi, Ghana. Ghana Medical Journal, 46, 14-21.
[6]  Eghan, B. and Acheampong, J.W. (2003) Dyslipidemia in Outpatients at General Hospital in Kumasi, Ghana: Cross-Sectional Study. Croatian Medical Journal, 44, 576-578.
[7]  Owiredu, W., Adamu, M., Amidu, N., et al. (2008) Obesity and Cardiovascular Risk Factors in a Pentecostal Population in Kumasi-Ghana. Journal of Medical Science, 8, 682-690. https://doi.org/10.3923/jms.2008.682.690
[8]  Owusu, I., Aryee, C., Owiredu, W., Osei-Yeboah, J., Owusu-Dabo, E. and Laing, E. (2015) Analysis of Atherogenic and Anthropometric Profiles of Normotensive and Hypertensive Ghanaians in the Kumasi Metropolis. British Journal of Medicine and Medical Research, 7, 378-397. https://doi.org/10.9734/BJMMR/2015/14308
[9]  Kirkendall, W.M., Burton, A.C., Epstein, F.H. and Freis, E.D. (1967) Recommendations for Human Blood Pressure Determination by Sphygmomanometers. Circulation, 36, 980-988. https://doi.org/10.1161/01.CIR.36.6.980
[10]  Bannerman, E., Miller, M.D., Daniels, L.A., et al. (2002) Anthropometric Indices predict Physical Function and Mobility in Older Australians: The Australian Longitudinal Study of Ageing. Public Health Nutrition, 5, 655-662. https://doi.org/10.1079/PHN2002336
[11]  Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972) Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, without Use of the Preparative Ultracentrifuge. Clinical Chemistry, 18, 499-502.
[12]  DeLong, D.M., DeLong, E.R., Wood, P.D., Lippel, K. and Rifkind, B.M. (1986) A Comparison of Methods for the Estimation of Plasma Low-and Very Low-Density Lipoprotein Cholesterol: The Lipid Research Clinics Prevalence Study. JAMA, 256, 2372-2377. https://doi.org/10.1001/jama.1986.03380170088024
[13]  Brindle, P., Jonathan, E., Lampe, F., et al. (2003) Predictive Accuracy of the Framingham Coronary Risk Score in British Men: Prospective Cohort Study. BMJ, 327, 1267. https://doi.org/10.1136/bmj.327.7426.1267
[14]  Lansky, A.J., Mintz, G.S., Popma, J.J., et al. (1998) Remodeling after Directional Coronary Atherectomy (with and without Adjunct Percutaneous Transluminal Coronary Angioplasty): A Serial Angiographic and Intravascular Ultrasound Analysis from the Optimal Atherectomy Restenosis Study. Journal of the American College of Cardiology, 32, 329-337. https://doi.org/10.1016/S0735-1097(98)00245-9
[15]  The DECODA Study Group (2003) Age-and Sex-Specific Prevalence of Dia-betes and Impaired Glucose Regulation in 11 Asian Cohorts. Diabetes Care, 26, 1770- 1780. https://doi.org/10.2337/diacare.26.6.1770
[16]  Pai, J.K., Pischon, T., Ma, J., et al. (2004) Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women. New England Journal of Medicine, 351, 2599-2610. https://doi.org/10.1056/NEJMoa040967
[17]  Hu, F.B., Meigs, J.B., Li, T.Y., Rifai, N. and Manson, J.E. (2004) Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women. Diabetes, 53, 693-700. https://doi.org/10.2337/diabetes.53.3.693
[18]  Marques-Vidal, P., Schmid, R., Bochud, M., et al. (2012) Adipocytokines, Hepatic and Inflammatory Biomarkers and Incidence of Type 2 Diabetes. The CoLaus Study. PLoS ONE, 7, e51768. https://doi.org/10.1371/journal.pone.0051768
[19]  Selby, J.V., Friedman, G.D. and Quesenberry, C.P. (1989) Precursors of Essential Hypertension: The Role of Body Fat Distribution Pattern. American Journal of Epidemiology, 129, 43-53. https://doi.org/10.1093/oxfordjournals.aje.a115123
[20]  Kotsis, V., Stabouli, S., Papakatsika, S., Rizos, Z. and Parati, G. (2010) Mechanisms of Obesity-Induced Hypertension. Hypertension Research, 33, 386-393.
[21]  Pitsavos, C., Tampourlou, M., Panagiotakos, D.B., et al. (2007) Association between Low-Grade Systemic Inflammation and Type 2 Diabetes Mellitus among Men and Women from the ATTICA Study. The Review of Diabetic Studies, 4, 98. https://doi.org/10.1900/RDS.2007.4.98
[22]  Agrawal, Y., Goyal, V., Chugh, K., Shanker, V. and Singh, A.A. (2014) Types of Dyslipidemia in Type 2 Diabetic Patients of Haryana Region. Scholars Journal of Applied Sciences, 2, 1385-1392.
[23]  Idogun, E., Unuigbe, E., Ogunro, P., Akinola, O. and Famodu, A. (2007) Assessment of Serum Lipids in Nigerians with Type 2 Diabetes Mellitus Complications. Pakistan Journal of Medical Sciences, 23, 708.
[24]  Gordon, L., Ragoobirsingh, D., Morrison, E., McGrowder, D., Choo-Kang, E. and Martorell, E. (2010) Dyslipidaemia in Hypertensive Obese Type 2 Diabetic Patients in Jamaica. Archives of Medical Science, 6, 701-708. https://doi.org/10.5114/aoms.2010.17084
[25]  Idemudia, J. (2014) Dyslipidaemia in Hypertensives in South-South Nigeria. British Journal of Medicine and Medical Research, 4, 4742-4750. https://doi.org/10.9734/BJMMR/2014/10678
[26]  Nyarko, A., Adubofour, K., Ofei, F., Kpodonu, J. and Owusu, S. (1997) Serum Lipid and Lipoprotein Levels in Ghanaians with Diabetes Mellitus and Hypertension. Journal of the National Medical Association, 89, 191.
[27]  Acquah, S., Boampong, J.N., Adusu, J., Achampong, E.K., Setorglo, J. and Obiri-Yeboah, D. (2012) Lipid and Lipoprotein Levels in Type 2 Diabetes Patients Attending the Central Regional Hospital in the Cape Coast Metropolis of Ghana. International Journal of Health Research, 4, 75-82.
[28]  Rader, D.J. (2012) High-Density Lipoprotein Particle Number: A Better Measure to Quantify High-Density Lipoprotein? Journal of the American College of Cardiology, 60, 517-520. https://doi.org/10.1016/j.jacc.2012.03.058
[29]  Kastelein, J.J., van Leuven, S.I., Burgess, L., et al. (2007) Effect of Torcetrapib on Carotid Atherosclerosis in Familial Hypercholesterolemia. New England Journal of Medicine, 356, 1620-1630. https://doi.org/10.1056/NEJMoa071359
[30]  Titty, F. (2010) Glycaemic Control, Dyslipidaemia and Metabolic Syndrome among Recently Diagnosed Diabetes Mellitus Patients in Tamale Teaching Hospital, Ghana. West African Journal of Medicine, 29, 8-11. https://doi.org/10.4314/wajm.v29i1.55946
[31]  Avramoglu, R.K., Basciano, H. and Adeli, K. (2006) Lipid and Lipoprotein Dysregulation in Insulin Resistant States. Clinica Chimica Acta, 368, 1-19.
[32]  Parchman, M.L., Zeber, J.E., Romero, R.R. and Pugh, J.A. (2007) Risk of Coronary Artery Disease in Type 2 Diabetes and the Delivery of Care Consistent with the Chronic Care Model in Primary Care Settings: A STARNet Study. Medical Care, 45, 1129-1134. https://doi.org/10.1097/MLR.0b013e318148431e
[33]  Grundy, S.M., Pasternak, R., Greenland, P., Smith, S. and Fuster, V. (1999) Assessment of Cardiovascular Risk by Use of Multiple-Risk-Factor Assessment Equationsa Statement for Healthcare Professionals from the American Heart Association and the American College of Cardiology. Journal of the American College of Cardiology, 34, 1348-1359. https://doi.org/10.1016/S0735-1097(99)00387-3
[34]  Kengne, A.P., Amoah, A.G. and Mbanya, J.-C. (2005) Cardiovascular Complications of Diabetes Mellitus in Sub-Saharan Africa. Circulation, 112, 3592-3601. https://doi.org/10.1161/CIRCULATIONAHA.105.544312
[35]  Huxley, R., Barzi, F. and Woodward, M. (2006) Excess Risk of Fatal Coronary Heart Disease Associated with Diabetes in Men and Women: Meta-Analysis of 37 Prospective Cohort Studies. BMJ, 332, 73-78. https://doi.org/10.1136/bmj.38678.389583.7C
[36]  Wingard, D.L., Barrett-Connor, E.L. and Ferrara, A. (1995) Is Insulin Really a Heart Disease Risk Factor? Diabetes Care, 18, 1299-1304. https://doi.org/10.2337/diacare.18.9.1299
[37]  Fuller, J., Keen, H., Jarrett, R., et al. (1979) Haemostatic Variables Associated with Diabetes and Its Complications. British Medical Journal, 2, 964. https://doi.org/10.1136/bmj.2.6196.964

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