Goblet cell carcinoid tumor is a rare clinical
entity which is usually diagnosed either as acute appendicitis or advanced
cancer. Its main characteristic is that the histological findings are between
those of adenocarcinoma and typical carcinoid tumor of the appendix. Goblet
cell carcinoid tumors appear almost exclusively in the appendix, and prognosis
depends mainly on the stage and the subtype of the histological classification.
We report three cases of goblet cell carcinoid tumor in the appendix with
different clinical presentation and evolution: a 60-year-old male admitted to
the emergency room with acute abdominal pain, diagnosed with acute appendicitis
and treated with laparoscopic appendectomy; a 65-year-old male undergoing right
hemicolectomy to remove a cecal adenoma, with a goblet cell carcinoid tumor
found incidentally in the surgical specimen; and a 77-year-old male with acute
appendicitis. We discuss the main pathological and clinical findings, and
propose a set of guidelines for clinical practice.
Cite this paper
Alvarez-Laso, C. , Azcano, E. , Carrion, J. F. , Rodríguez, D. and Riera, J. R. (2017). Goblet Cell Carcinoid Tumors of the Appendix: A Report of Two Cases, Review of a Rare Clinical Entity, and Guidelines for Treatment. Open Access Library Journal, 4, e3256. doi: http://dx.doi.org/10.4236/oalib.1103256.
Roy, P.
and
Chetty, R. (2010)
Goblet Cell Carcinoid Tumors of the Appendix: An Overview. World Journal of Gastrointestinal Oncology, 2, 251-258. https://doi.org/10.4251/wjgo.v2.i6.251
Isaacson, P.
(1981) Crypt
Cell Carcinoma of the Appendix (So-Called Adenocarcinoid Tumor). The American Journal of Surgical Pathology, 5, 213-224. https://doi.org/10.1097/00000478-198104000-00001
Bosman, F.,
Carneiro, F., Hruban, R.
and Theise, N.D. (2010) WHO
Classification of Tumors of the Digestive System. International Agency for
Research on Cancer, Lyon.
McCusker, M.E.,
Cote, T.R.,
Clegg, L.X.
and
Sobin, L.H. (2002) Primary
Malignant Neoplasms of the Appendix: A Population-Based Study from the Surveillance,
Epidemiology and End-Results Program, 1973-1998. Cancer, 94, 3307-3312. https://doi.org/10.1002/cncr.10589
Tang, L.H.,
Shia, J.,
Soslow, R.A.,
Dhall, D.,
Wong, W.D.,
O’Reilly, E., et al. (2008) Pathologic
Classification and Clinical Behavior of the Spectrum of Goblet Cell Carcinoid Tumors
of the Appendix. The American Journal of
Surgical Pathology, 32, 1429-1443. https://doi.org/10.1097/PAS.0b013e31817f1816
Romeo,
M.,
Quer,
A.,
Tarrats,
A.,
Molina,
C.,
Radua,
J.
and
Manzano,
J.L.
(2015)
Appendiceal
Mixed Adenoneuroendocrine Carcinomas, a Rare Entity That Can Present as a Krukenbergtumor:
Case Report and Review of the Literature. World
Journal of Surgical Oncology, 13, 325. https://doi.org/10.1186/s12957-015-0740-1
Kanthan, R.,
Saxena, A.
and
Kanthan, S.C. (2001) Goblet
Cell Carcinoids of the Appendix: Immunophenotype and Ultrastructural Study. Archives of Pathology & Laboratory Medicine, 125, 386-390.
Pahlavan, P.S.
and
Kanthan, R. (2005)
Goblet Cell Carcinoid of the Appendix. World
Journal of Surgical Oncology, 3, 36. https://doi.org/10.1186/1477-7819-3-36
Pham, T.H.,
Wolff, B.,
Abraham, S.C.
and
Drelichman, E. (2006)
Surgical and Chemotherapy Treatment Outcomes of Goblet Cell Carcinoid: A
Tertiary Cancer Center Experience. The
Annals of Surgical Oncology, 13, 370-376. https://doi.org/10.1245/ASO.2006.02.016
Garin, L.,
Corbinais, S.,
Boucher, E.,
Blanchot, J.,
Le Guilcher, P.
and
Raoul, J.L. (2002)
Adenocarcinoid of the
Appendix Vermiformis: Complete and Persistent Remission after Chemotherapy (Folfox)
of Metastatic Case. Digestive Diseases
and Sciences, 47,
2760-2762. https://doi.org/10.1023/A:1021065407822
Thirlby, R.C.,
Kasper, C.S.
and
Jones, R.C. (1984)
Metastatic Carcinoid Tumor of the Appendix. Report of a Case and Review of the
Literature. Diseases of the Colon &
Rectum, 27, 42-46. https://doi.org/10.1007/BF02554075