Background: The
association between pulmonary tuberculosis and a hypercoagulable state is well documented. An increased D-dimer level
is linked with increasing the mortality of pulmonary
tuberculosis infection. Objective: The current study aimed to the estimation and assessment of the D-dimer
levels in Sudanese patients with pulmonary tuberculosis. Material and Methods: This
is a case control study that was conducted during March 2016 at Faculty of Medical Laboratory Sciences,
Alneelain University, Khartoum, Sudan. A total of 70 subjects were included in this
study, classified into two groups.
The first group consists of 40 subjects, among which 30 (75%) were males and 10 (25%) were female; their mean age is 32.3 years
classified as patients group; of other 30 normal healthy subjects, 15 (50%)
were female and 15 (50%)
were males; their mean age was 33.1 years in the second group as normal control
group. The platelet poor plasma was prepared immediately from citrated blood by
centrifuging at 2000 rpm for 15 minutes. The data were collected by structured interview and questionnaire, and then analyzed by using a
computer program statistical package for social sciences (SPSS) version 21. The D-dimer levels were
measured using immunometric assay (Nyco Card READER II). Result: The present study found
that the D-dimer levels were statistically significantly higher in pulmonary tuberculosis patients compared
to the normal healthy control groups (Mean ± SD 0.82 ± 0.54 vs. 0.33 ± 0.13 with p value 0.00). Conclusion: This study
showed that Sudanese patient with pulmonary tuberculosis has increased the
plasma D-dimer level, and this abnormality could be prone to Deep Vein Thrombosis (DVT).
Cite this paper
Alhassan, S. A. A. and Gaufri, N. E. A. M. (2017). Estimation and Assessment of D-Dimer Levels in Sudanese Patients with Pulmonary Tuberculosis. Open Access Library Journal, 4, e3211. doi: http://dx.doi.org/10.4236/oalib.1103211.
Ryan,
K.J. and Ray, C.G. (2004) “Mycobacteria”. Sherris Medical
Microbiology: An Introduction to Infectious Diseases.
4th Edition, McGraw-Hill, New York,
439.
Bregani, E.R.,
Valcarenghi, C., Van
Tien, T.
and Monzani, V.
(2013) Suggestive
Criteria for Pulmonary Tuberculosis in Developing Countries. International Journal of Mycobacteriology, 2,
211-213.
Malani, P.N. (2010) Mandell, Douglas, and
Bennett’s Principles and Practice of Infectious Diseases. JAMA, 304, 2067-2071. https://doi.org/10.1001/jama.2010.1643
El Fekih, L., Oueslati, I., Hassene, H., Fenniche, S., Belhabib, D. and Megdiche,
M.L. (2009)
Association Thromboses Veineuses Profondes avec Tuberculose Pulmonaire. Tunis
Med, 87, 328-329.
Petersen,
K. (2010) Mandell,
Douglas, and Bennett’s
Principles and Practice of Infectious Diseases. In:
Mandell, G.L.,
Bennett, J.E. and
Dolin, R.,
Eds., Vol.
51, Churchill
Livingstone Elsevier, Philadelphia, 636-637.
Philip-Joet,
F., Alessi, M.C.,
Philip-Joet, C.,
Aillaud, M.,
Barriere, J.R., Arnaud,
A.
and Juhan-Vague, I. (1995) Fibrinolytic
and Inflammatory Processes in Pleural Effusions. European Respiratory Journal, 8, 1352-1356.
Eldin, G.S.S., Fadl-Elmula, I., Ali, M.S., Ali, A.B., Salih,
A.L.G., Mallard, K., Bottomley, C. and Mcnerney,
R. (2011)
Tuberculosis in Sudan: A Study of Mycobacterium
tuberculosis Strain Genotype and Susceptibility to Anti-Tuberculosis Drugs. BMC Infectious Diseases,
11, 1.
Robson, S.C., White, N.W., Aronson, I., Woollgar, R., Goodman,
H. and Jacobs, P. (1996) Acute-Phase
Response and the Hypercoagulable State in Pulmonary Tuberculosis. British Journal
of Haematology, 93, 943-949. https://doi.org/10.1046/j.1365-2141.1996.d01-1722.x
Shen,
Y., Yang, T., Jia, L., Wang, T., Chen, L., Wan, C., Wang, L., Yan, Y. and Yi, Q. (2013) A Potential
Role for D-Dimer in the Diagnosis of Tuberculous Pleural Effusion. Age, 52, 15.
Zahn, D.W. and Peirce, C.T. (1948) Venous
Thrombosis and Pulmonary Embolism in Tuberculosis. The American Journal of Medicine, 5, 716-728. https://doi.org/10.1016/0002-9343(48)90149-1
Gupta,
D., Gupta, S., Balamugesh, T., Aggarwal, A.N. and Das, R. (2005) Circulating
D-Dimers as a Marker of Disease Activity in Pulmonary Sarcoidosis. Indian
Journal of Chest Diseases and Allied Sciences, 47, 175.
Christ-Crain, M., Morgenthaler, N.G., Stolz, D., Müller,
C., Bingisser, R., Harbarth, S., Tamm, M., Struck, J., Bergmann, A. and Müller, B. (2006) Pro-Adrenomedullin
to Predict Severity and Outcome in Community-Acquired Pneumonia. Critical
Care, 10,
R96.
Kager, L.M., Blok, D.C., Lede, I.O., Rahman, W., Afroz,
R., Bresser, P., Van der Zee, J. S., Ghose, A., Visser, C.E. and De Jong, M.D. (2015)
Pulmonary Tuberculosis Induces a Systemic Hypercoagulable State. Journal of
Infection, 70, 324-334. https://doi.org/10.1016/j.jinf.2014.10.006
